45376-79-2

Basic information

• Product Name: 1H-Imidazole, 1-hydroxy-
• Synonyms: 1-hydroxyimidazole;hydroxy imidazole;hydroxyimidazole;N-hydroxyimidazole;N-hydroxy imidazole
• CAS NO: 45376-79-2
• Molecular Formula: C3H4N2O
• Molecular Weight: 84.0776
• Mol File: 45376-79-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 282.2±23.0 °C(Predicted)
• Density: 1.30±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 1H-Imidazole, 1-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole, 1-hydroxy-(45376-79-2)
• EPA Substance Registry System: 1H-Imidazole, 1-hydroxy-(45376-79-2)

Safety Data

• Hazardous Substances Data: 45376-79-2(Hazardous Substances Data)

Upstream product

• 288-32-4 1H-imidazole 
• 35321-46-1 1-hydroxy-1H-imidazole-3-oxide 

Downstream Products

• 126355-38-2 1-trityloxy-1H-imidazole 
• 131468-91-2 1-Phenethyloxy-1H-imidazole 
• 548765-40-8 methyl-phenyl-carbamic acid imidazol-1-yl ester 
• 548767-52-8 Morpholine-4-carboxylic acid imidazol-1-yl ester 
• 126355-49-5 1-(2,4-Dichloro-benzyloxy)-1H-imidazole 
• 126355-47-3 allyloxyimidazole 
• 126355-39-3 1-phenoxy-1H-imidazole 
• 121779-19-9 1-(benzyloxy)imidazole 
• 131468-90-1 1-Methoxy-1H-imidazole 

Relevant articles and documents

Synthesis of 2-Substituted 1-Hydroxyhnidazoles through Directed Lithiation

Benzylation of 3-hydroxyimidazole 1-oxide gave 3-(benzyloxy)imidazole 1-oxide, which was deoxygenated with phosphorous trichloride to produce 1-(benzyloxy)imidazole. 1-(Benzyloxy)imidazole was deprotonated selectively at C-2 by n-butyllithium. The anion formed was reacted with electrophiles to give 1-(benzyloxy)imidazoles with carbon, halogen, silicon, or sulfur substituents at the 2-position. Subsequent debenzylation afforded 2-substituted 1-hydroxyimidazoles which in turn could be deoxygenated to give 2-substituted imidazoles.