4538-16-3

Basic information

• Product Name: 5-OXO-4,5-DIHYDRO-1H-[1,2,4]TRIAZOLE-3-CARBOXYLIC ACID
• Synonyms: 5-OXO-4,5-DIHYDRO-1H-[1,2,4]TRIAZOLE-3-CARBOXYLIC ACID;AKOS AU36-M362;ASINEX-REAG BAS 10142521;5-keto-1,2-dihydro-1,2,4-triazole-3-carboxylic acid;5-oxo-1,2-dihydro-1,2,4-triazole-3-carboxylic acid
• CAS NO: 4538-16-3
• Molecular Formula: C₃H₃N₃O₃
• Molecular Weight: 129.07
• Mol File: 4538-16-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-OXO-4,5-DIHYDRO-1H-[1,2,4]TRIAZOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-OXO-4,5-DIHYDRO-1H-[1,2,4]TRIAZOLE-3-CARBOXYLIC ACID(4538-16-3)
• EPA Substance Registry System: 5-OXO-4,5-DIHYDRO-1H-[1,2,4]TRIAZOLE-3-CARBOXYLIC ACID(4538-16-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 4538-16-3(Hazardous Substances Data)

Usage

Uses

5-Oxo-2,5-dihydro-1H-1,2,4-triazole-3-carboxylic Acid is used in preparation of the fused tri-cyclic compound as pde3/pde4 dual inhibitor.

Upstream product

• 3641-13-2 5-amino-1H-[1,2,4]triazole-3-carboxylic acid 
• 42839-64-5 1-(Phenylmethyleneamino)imidazole-2,4,5-(1H,3H)-trione 
• 409317-13-1 oxalic acid bis-(N'-carbamoyl-hydrazide) 

Downstream Products

• 930-33-6 3-H-1,2-dihydro-1,2,4-triazol-3-one 
• 930-33-6 2,4-dihydro-1,2,4-triazol-3-one 

Relevant articles and documents

Chemoenzymatic method of 1,2,4-triazole nucleoside synthesis: Possibilities and limitations

Possibilities and limitations of chemoenzymatic synthesis of novel structural analogues of an antiviral preparation of Ribavirin (1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) were established. A synthesis of various amides of 1H-1,2,4-triazole-3-carboxylic acid and its 5-substituted analogues - potential substrates of purine nucleoside phosphorylase - has been described. Comparative efficiency of preparation methods of these amides, as well as the methods of introduction of functional groups to the C5 position of heterocyclic system, were investigated. Novel analogues of Ribavirin containing various substitutes in the carboxamide group were synthesized. A biotechnological method was developed for the preparation of 1-β-D-ribofuranozyl-1,2,4-triazole-3-carbonitryl, an intermediate in the synthesis of Viramidine, the modern analogue of Ribavirin.