4538-16-3 Usage
Uses
1. Pharmaceutical Industry:
5-OXO-4,5-DIHYDRO-1H-[1,2,4]TRIAZOLE-3-CARBOXYLIC ACID is used as a key intermediate in the synthesis of pharmaceutical compounds. Its unique structure allows it to be a versatile building block for the development of new drugs with potential therapeutic applications.
2. Preparation of Fused Tri-Cyclic Compounds:
In the field of medicinal chemistry, 5-OXO-4,5-DIHYDRO-1H-[1,2,4]TRIAZOLE-3-CARBOXYLIC ACID is used as a starting material for the preparation of fused tri-cyclic compounds. These compounds have shown potential as PDE3/PDE4 dual inhibitors, which are important targets for the treatment of various diseases, including cardiovascular and respiratory disorders.
3. Research and Development:
5-OXO-4,5-DIHYDRO-1H-[1,2,4]TRIAZOLE-3-CARBOXYLIC ACID is also used in academic and industrial research laboratories for the development of new chemical entities and the study of their biological activities. Its unique structure and reactivity make it an attractive candidate for exploring novel chemical reactions and potential applications in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 4538-16-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,5,3 and 8 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 4538-16:
(6*4)+(5*5)+(4*3)+(3*8)+(2*1)+(1*6)=93
93 % 10 = 3
So 4538-16-3 is a valid CAS Registry Number.
4538-16-3Relevant academic research and scientific papers
Chemoenzymatic method of 1,2,4-triazole nucleoside synthesis: Possibilities and limitations
Konstantinova,Chudinov,Fateev,Matveev,Zhurilo,Shvets,Miroshnikov
, p. 53 - 71 (2013/04/10)
Possibilities and limitations of chemoenzymatic synthesis of novel structural analogues of an antiviral preparation of Ribavirin (1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) were established. A synthesis of various amides of 1H-1,2,4-triazole-3-carboxylic acid and its 5-substituted analogues - potential substrates of purine nucleoside phosphorylase - has been described. Comparative efficiency of preparation methods of these amides, as well as the methods of introduction of functional groups to the C5 position of heterocyclic system, were investigated. Novel analogues of Ribavirin containing various substitutes in the carboxamide group were synthesized. A biotechnological method was developed for the preparation of 1-β-D-ribofuranozyl-1,2,4-triazole-3-carbonitryl, an intermediate in the synthesis of Viramidine, the modern analogue of Ribavirin.
