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6-Bromo-2-methyl-3-(o-tolyl)quinazolin-4(3H)-one is a complex organic compound with the molecular formula C16H13BrN2O. It is a derivative of quinazolinone, a heterocyclic compound with potential applications in medicinal chemistry, particularly as a building block for the synthesis of various bioactive molecules. The structure of 6-BroMo-2-Methyl-3-(o-tolyl)quinazolin-4(3H)-one features a quinazolinone core with a bromine atom at the 6-position, a methyl group at the 2-position, and an o-tolyl (2-methylphenyl) group at the 3-position. This specific arrangement of functional groups may confer unique chemical and biological properties to the molecule, making it a subject of interest for further research and development in the field of drug design and synthesis.

4538-23-2

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4538-23-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4538-23-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,5,3 and 8 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 4538-23:
(6*4)+(5*5)+(4*3)+(3*8)+(2*2)+(1*3)=92
92 % 10 = 2
So 4538-23-2 is a valid CAS Registry Number.

4538-23-2Downstream Products

4538-23-2Relevant academic research and scientific papers

Atropisomeric quinazolin-4-one derivatives are potent noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists

Welch,Ewing,Huang,Menniti,Pagnozzi,Kelly,Seymour,Guanowsky,Guhan,Guinn,Critchett,Lazzaro,Ganong,DeVries,Staigers,Chenard

, p. 177 - 181 (2007/10/03)

Piriqualone (1) was found to be an antagonist of AMPA receptors. Structure-activity optimization was conducted on each of the three rings in 1 to afford a series of potent and selective antagonists. The sterically crowded environment surrounding the N-3 aryl group provided sufficient thermal stability for atropisomers to be isolated. Separation of these atropisomers resulted in the identification of (+)-38 (CP-465,022), a compound that binds to the AMPA receptor with high affinity (IC50 = 36 nM) and displays potent anticonvulsant activity.

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