4540-60-7Relevant articles and documents
Preparation method of cannabidiol compound
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Paragraph 0061-0062, (2020/12/30)
The invention discloses a preparation method of a compound with a general formula I or pharmaceutically acceptable salts, stereoisomers, esters, prodrugs and solvates thereof, which comprises the following steps: (1) by using a compound A and (1S, 4R) 1methyl 4 (1methyl vinyl) 2cyclohexene 1alcohol as raw materials, carrying out coupling under the action of a chiral imidazolone salt catalyst to obtain a compound B; carrying out sodium sulfite dehalogenation and alkali washing to obtain an intermediate 1; (2) heating the intermediate 1 to 80100 DEG C under the action of DMSO, lithium chloride and an antioxidant, reacting, and recrystallizing to obtain a compound with a general formula I;.
Synthetic method for chiral alpha-aminoamide compounds
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Paragraph 0048; 0049; 0050, (2018/01/11)
The invention provides a synthetic method for chiral alpha-aminoamide compounds, belongs to the technical field of organic synthetic methodology, and concretely relates to a synthetic method for chiral alpha-aminoamide compounds, wherein the method has a simple process, low costs and good economy. The method comprises the following steps: 1, performing ammonolysis: adding substituted chiral alpha-aminocarboxylate hydrochloride into concentrated ammonia water, performing stirring for 4-12h under a room temperature, wherein each 1mmol substituted chiral alpha-aminocarboxylate hydrochloride is corresponding to 2-8mL the concentrated ammonia water; 2, after a reaction is finished, performing distillation for removing ammonia water after the reaction to obtain crude products chiral alpha-aminoamide compounds; and 3, performing filtration on the obtained crude products chiral alpha-aminoamide compounds by adopting a manner of adding a solvent or performing purification on the obtained crude products chiral alpha-aminoamide compounds through a manner of column chromatography which uses ammonia water as a mobile phase to obtain the products chiral alpha-aminoamide compounds. Compared with the prior art, a large number of an ammonia gas for ammonolysis is not needed in the method, the process and post-treatment are simple, costs are low and reaction time is short.
Enantiospecific C-H Activation Using Ruthenium Nanocatalysts
Taglang, Céline,Martínez-Prieto, Luis Miguel,Del Rosal, Iker,Maron, Laurent,Poteau, Romuald,Philippot, Karine,Chaudret, Bruno,Perato, Serge,Sam Lone, Ana?s,Puente, Céline,Dugave, Christophe,Rousseau, Bernard,Pieters, Grégory
supporting information, p. 10474 - 10477 (2015/09/02)
The activation of C-H bonds has revolutionized modern synthetic chemistry. However, no general strategy for enantiospecific C-H activation has been developed to date. We herein report an enantiospecific C-H activation reaction followed by deuterium incorporation at stereogenic centers. Mechanistic studies suggest that the selectivity for the α-position of the directing heteroatom results from a four-membered dimetallacycle as the key intermediate. This work paves the way to novel molecular chemistry on nanoparticles.