454169-97-2Relevant academic research and scientific papers
Potent, nonsteroidal selective androgen receptor modulators (SARMs) based on 8H-[1,4]oxazino[2,3-f]quinolin-8-ones
Higuchi, Robert I.,Thompson, Anthony W.,Chen, Jyun-Hung,Caferro, Thomas R.,Cummings, Marquis L.,Deckhut, Charlotte P.,Adams, Mark E.,Tegley, Christopher M.,Edwards, James P.,Lopez, Francisco J.,Kallel, E. Adam,Karanewsky, Donald S.,Schrader, William T.,Marschke, Keith B.,Zhi, Lin
, p. 5442 - 5446 (2008/03/13)
A series of androgen receptor modulators based on 8H-[1,4]oxazino[2,3-f]quinolin-8-ones was synthesized and evaluated in an androgen receptor transcriptional activation assay. The most potent analogues from the series exhibited single-digit nanomolar potency in vitro. Compound 18h demonstrated full efficacy in the maintenance of muscle weight, at 10 mg/kg, with reduced activity in prostate weight in an in vivo model of androgen action.
Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods
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, (2008/06/13)
Novel non-steroidal tricyclic quinolinone and tricyclic quinoline compounds and compositions that are agonists, partial agonists and/or antagonists for androgen receptors (AR), their preparation and their uses are described.
