454181-99-8

Upstream product

• 19064-67-6 6-chloro-2H-pyridazin-3-one 
• 1122-41-4 2,4-dichlorobenzenethiol 

Relevant academic research and scientific papers

Sulfonyl pyridazinone compounds useful as aldose reductase inhibitors

This invention relates to novel sulfonyl pyridazinone compounds useful as aldose reductase inhibitors in the treatment or prevention of certain complications arising from diabetes mellitus, pharmaceutical compositions comprising the sulfonyl pyridazinone, pharmaceutical compositions comprising a combination of the sulfonyl pyridazinone together with a second pharmaceutical agent, therapeutic methods comprising the administration of the sulfonyl pyridazinone compounds, therapeutic methods comprising the administration of the sulfonyl pyridazinone compounds in combination with a second pharmaceutical agent and compounds useful as intermediates for preparing the sulfonyl pyridazinone compounds of this invention.

Therapies for tissue damage resulting from ischemia

This invention relates to therapeutic methods for treatment or prevention of tissue damage resulting from ischemia in mammals.

Sulfonyl pyridazinone compounds as therapeutic agents for ischemic tissue damage

This invention relates to therapeutic methods for treatment or prevention of tissue damage resulting from ischemia in mammals.

Sulfonyl pyridazinone compounds useful as aldose reductase inhibitors

Compounds of the formula (I): a prodrug thereof or a pharmaceutically acceptable salt of said compound or said prodrug, wherein R1, R2, X and Y are as defined in the claims are aldose reductase inhibitors useful in the treatment or p