45427-50-7

Usage

Uses

Used in Chemical Synthesis:
1,3,5-Triazine, 1,2-dihydrois used as an intermediate for the synthesis of various organic chemicals and pharmaceuticals, contributing to the development of a wide range of products in the chemical industry.
Used in Pharmaceutical Industry:
As a building block, 1,3,5-Triazine, 1,2-dihydrois utilized in the synthesis of heterocyclic compounds, which are essential components in the creation of pharmaceuticals with specific therapeutic properties.
Used in Organic Synthesis:
1,3,5-Triazine, 1,2-dihydrofunctions as a reagent in organic synthesis, enabling chemists to create new compounds with tailored chemical properties for various applications, including but not limited to materials science, agrochemicals, and specialty chemicals.

Upstream product

• 290-87-9 1,3,5-Triazine 

Relevant academic research and scientific papers

Ru-Catalyzed Transfer Hydrogenation of Nitriles, Aromatics, Olefins, Alkynes and Esters

This paper reports the preparation of new ruthenium(II) complexes supported by a pyrazole-phosphine ligand and their application to transfer hydrogenation of various substrates. These Ru complexes were found to be efficient catalysts for the reduction of nitriles and olefins. Heterocyclic compounds undergo transfer hydrogenation with good to moderate yields, affording examples of unusual hydrogenation of all-carbon-rings. Internal alkynes with bulky substituents show selective reduction to olefins with the unusual E–selectivity. Esters with strong electron-withdrawing groups can be reduced to the corresponding alcohols, if ethanol is used as the solvent. Possible mechanisms of hydrogenation and olefin isomerization are suggested on the basis of kinetic studies and labelling experiments.

Transfer Hydrogenation of Nitriles, Olefins, and N-Heterocycles Catalyzed by an N-Heterocyclic Carbene-Supported Half-Sandwich Complex of Ruthenium

In the presence of KOBut, N-heterocyclic carbene-supported half-sandwich complex [Cp(IPr)Ru(pyr)2][PF6] (3) (IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene) catalyzes transfer hydrogenation (TH) of nitriles, activated N-heterocycles, olefins, and conjugated olefins in isopropanol at the catalyst loading of 0.5%. The TH of nitriles leads to imines, produced as a result of coupling of the initially formed amines with acetone (produced from isopropanol), and showed good chemoselectivity. Reduction of N-heterocycles occurs for activated polycyclic substrates (e.g., quinoline) and takes place exclusively in the heterocycle. The TH also works well for linear and cyclic olefins but fails for trisubstituted substrates. However, the C = C bond of α,β-unsaturated esters, amides, and acids is easily reduced even for trisubstituted species, such as isovaleriates. Mechanistic studies suggest that the active species in these catalytic reactions is the trihydride Cp(IPr)RuH3 (5), which can catalyze these reactions in the absence of any base. Kinetic studies are consistent with a classical inner sphere hydride-based mechanism of TH.

Process for the preparation of hydroxyphenyl-1,3,5-triazines

A simple process for the preparation of a triazine of formula (1) is described, which comprises converting a dihydrotriazine of formula (2) with a reducing agent to a 1,3,5-triazine of formula (1). The triazines obtained by the novel process are suitable UV absorbers for organic materials, in particular for polyester fiber materials, or suitable starting materials for the preparation of UV absorbers.