454451-28-6

Basic information

• Product Name: BOC-4-AMINOHEXAHYDRO-4H-AZEPINE
• Synonyms: BOC-4-AMINOHEXAHYDRO-4H-AZEPINE;CARBAMIC ACID, (HEXAHYDRO-1H-AZEPIN-4-YL)-, 1,1-DIMETHYLETHYL ESTER;4-(N-BOC-AMINO)-1H-AZEPINE;Carbamic acid, (hexahydro-1H-azepin-4-yl)-, 1,1-dimethylethyl ester (9CI);B52040;4-(N-Boc-aMino)-1H-Azepin...;(Hexahydro-1H-azepin-4-yl)carbamic acid 1,1-dimethylethyl ester;BOC-4-aMinohexahhydro-4H-azepine
• CAS NO: 454451-28-6
• Molecular Formula: C11H22N2O2
• Molecular Weight: 214.3
• Product Categories: N-BOC
• Mol File: 454451-28-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 322.7 °C at 760 mmHg
• Flash Point: 149 °C
• Appearance: /
• Density: 1.01
• Storage Temp.: 2-8°C
• PKA: 12.51±0.20(Predicted)
• CAS DataBase Reference: BOC-4-AMINOHEXAHYDRO-4H-AZEPINE(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-4-AMINOHEXAHYDRO-4H-AZEPINE(454451-28-6)
• EPA Substance Registry System: BOC-4-AMINOHEXAHYDRO-4H-AZEPINE(454451-28-6)

Safety Data

• Hazardous Substances Data: 454451-28-6(Hazardous Substances Data)

Usage

Uses

tert-Butyl Azepan-4-ylcarbamate is used in preparation of cytosine derivatives as antimicrobial agents for the treatment of bacterial infections.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1017575-23-3 benzyl (4S)-4-aminoazepane-1-carboxylate 
• 1017575-40-4 benzyl (4S)-4-tert-butoxycarbonylaminoazepane-1-carboxylate 

Relevant articles and documents

Side chain SAR of bicyclic β-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712

The bridged monobactam β-lactamase inhibitor MK-8712 (1) effectively inhibits class C β-lactamases. Side chain N-alkylated and ring-opened analogs of 1 were prepared and evaluated for combination with imipenem to overcome class C β-lactamase mediated resi

Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions

The present invention relates to substituted xanthines of general formula wherein R1 to R4 are defined as in claim 1, the tautomers and the stereoisomers thereof, mixtures thereof, the prodrugs and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).