454466-57-0

Upstream product

• 100-83-4 meta-hydroxybenzaldehyde 
• 79-22-1 methyl chloroformate 

Downstream Products

• 1252004-24-2 3-(diacetoxymethyl)phenyl methyl carbonate 
• 20357-24-8 5-methoxy-2-nitro-benzaldehyde 
• 681446-84-4 4-hydroxy-4-(5-methoxy-2-nitrophenyl)butan-2-one 
• 1252004-29-7 4-methoxy-2-{(E)-[(4-methylphenyl)imino]methyl}aniline 
• 887578-89-4 N-[(1E)-(5-methoxy-2-nitrophenyl)methylene]-4-methylaniline 
• 1252004-25-3 3-{(E)-[(4-methylphenyl)imino]methyl}-4-nitrophenol 
• 1252004-27-5 4-amino-3-{(E)-[(4-methylphenyl)imino]methyl}phenyl acetate 
• 1252004-26-4 3-{(E)-[(4-methylphenyl)imino]methyl}-4-nitrophenyl acetate 
• 1252004-28-6 4-methyl-N-{[2-nitro-5-(2-piperidin-1-ylethoxy)phenyl]methylene}aniline 
• 485844-02-8 2-nitro-5-(2-piperidin-1-ylethoxy)benzaldehyde 
• 848142-62-1 3-chloro-2-(4-hydroxyphenyl)-2H-indazol-5-ol 
• 640293-17-0 2,1-benzisoxazole-4,5-dione 4-oxime 
• 831222-24-3 isoxazolo[3,4-e][2,1]benzisoxazole 
• 454466-62-7 benzo[c]isoxazol-5-ol? 

Relevant academic research and scientific papers

A general and efficient approach to 2H-indazoles and 1H-pyrazoles through copper-catalyzed intramolecular N-N bond formation under mild conditions

A new efficient copper-catalyzed intramolecular amination reaction has been developed to readily synthesise a wide variety of multi-substituted 2H-indazole and 1H-pyrazole derivatives from easily accessible starting materials under mild conditions. A highly selective ligand for estrogen receptor β was prepared in three steps by employing this method. The Royal Society of Chemistry 2011.

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedl?nder reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedl?nder condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.

Synthesis and preliminary evaluation of novel analogues of quindolines as potential stabilisers of telomeric G-quadruplex DNA

Telomeric DNA is a potential selective target for cancer therapy since the tumour-associated enzyme telomerase regulates telomere maintenance in most cancer cells. The 3′ single-stranded ends of telomeric DNA can be folded into quadruplex structures by appropriate small molecules. We describe the preparation of a new class of 2,7-disubstituted 10H-indolo[3,2-b]quinolines with enhanced selectivity for the stabilisation of quadruplex DNA compared to duplex DNA, and also the preparation of a key intermediate for the synthesis of trisubstituted quindolines.

A novel cyclization to isoxazolo[3,4-e][2,1]benzisoxazole

Methylation of 2,1-benzisoxazole 4,5-dione 4-oxime 2 using dimethyl sulfate in DMF and in the presence of potassium carbonate gave a substantial yield of isoxazolo[3,4-e][2,1]benzisoxazole 4 by an unexpected cyclization reaction of the O-methylation product 3.