454685-21-3

Basic information

• Product Name: 4,6-dihydroxy-5-(3-bromobenzyl)pyrimidine
• Synonyms: 4,6-dihydroxy-5-(3-bromobenzyl)pyrimidine
• CAS NO: 454685-21-3
• Molecular Weight: 281.109
• Mol File: 454685-21-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4,6-dihydroxy-5-(3-bromobenzyl)pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-dihydroxy-5-(3-bromobenzyl)pyrimidine(454685-21-3)
• EPA Substance Registry System: 4,6-dihydroxy-5-(3-bromobenzyl)pyrimidine(454685-21-3)

Safety Data

• Hazardous Substances Data: 454685-21-3(Hazardous Substances Data)

Upstream product

• 107558-73-6 diethyl 2-(3-bromobenzyl)-malonate 
• 3473-63-0 formamidine acetic acid 
• 823-78-9 meta-bromobenzyl bromide 

Downstream Products

• 454685-23-5 4,6-diiodo-5-(3-bromobenzyl)pyrimidine 
• 454685-24-6 4-amino-6-iodo-5-(3-bromobenzyl)pyrimidine 
• 454685-22-4 4,6-dichloro-5-(3-bromobenzyl)pyrimidine 

Relevant articles and documents

Design, synthesis, and structure-activity relationship of 6-alkynylpyrimidines as potent adenosine kinase inhibitors

Adenosine (ADO) is an extracellular signaling molecule within the central and peripheral nervous system. Its concentration is increased at sites of tissue injury and inflammation. One of the mechanisms by which antinociceptive and antiinflammatory effects of ADO can be enhanced consists of inhibition of adenosine kinase (AK), the primary metabolic enzyme for ADO. Novel nonnucleoside AK inhibitors based on 4-amino-6-alkynylpyrimidines were prepared, and the importance of the length of the linker at the 5-position for high affinity AK inhibition was demonstrated. Compounds with 2- and 3-atom linkers were the most potent AK inhibitors. Optimization of their physicochemical properties led to 31a and 37a that effectively reduced pain and inflammation in animal models.