4549-40-0 Usage
Chemical Properties
N-Nitrosomethylvinylamine is a yellow liquid.
Uses
Different sources of media describe the Uses of 4549-40-0 differently. You can refer to the following data:
1. N-nitrosomethylvinylamine is used as a research chemical; no other uses were identified (IARC 1978, HSDB 2009).
2. N-Methyl-N-nitroso-ethenamine is used as research reagent for base induced fragmentation to give aldehydes or ketones and smaller alkylnitrosamine
Production Methods
NMVA has not been produced commercially and is currently
produced in limited quantities for research purposes. There
are no reports that it occurs in the environment and exposure
is likely limited to researchers using NMVA.
General Description
Very volatile yellow liquid.
Air & Water Reactions
Water soluble but relatively unstable in water .
Health Hazard
ACUTE/CHRONIC HAZARDS: Methylvinylnitrosamine is highly toxic by ingestion and inhalation. When heated to decomposition, Methylvinylnitrosamine emits toxic fumes of NOx.
Fire Hazard
Flash point data for Methylvinylnitrosamine are not available; however Methylvinylnitrosamine is probably combustible.
Safety Profile
Confirmed carcinogen
with experimental tumorigenic data. Poison
by ingestion and inhalation. When heated to
decomposition it emits toxic fumes of NOx.
See also N-NITROSO COMPOUNDS and
AMINES.
Potential Exposure
This chemical is not manufactured but
occurs as a chemical reaction byproduct found in the dye,
automotive, rubber, and leather industries.
Carcinogenicity
N-Nitrosomethylvinylamine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Incompatibilities
Light sensitive. Incompatible with oxidizers
(chlorates, nitrates, peroxides, permanganates, perchlorates,
chlorine, bromine, fluorine, etc.); contact may cause
fires or explosions. Keep away from alkaline materials strong bases, strong acids, oxoacids, epoxides. A nitrated
amine. Amines are combustible. Azo, diazo, azido compounds
can detonate. This applies in particular to organic
azides that have been sensitized by the addition of metal
salts or strong acids. Toxic gases are formed by mixing
materials of this class with acids, aldehydes, amides, carbamates,
cyanides, inorganic fluorides, halogenated organics,
isocyanates, ketones, metals, nitrides, peroxides, phenols,
epoxides, acyl halides, and strong oxidizing or reducing
agents. Flammable gases are formed by mixing materials in
this group with alkali metals. Explosive combination can
occur with strong oxidizing agents, metal salts, peroxides,
and sulfides.
Waste Disposal
Consult with environmental
regulatory agencies for guidance on acceptable disposal
practices. Generators of waste containing this contaminant
(≥100 kg/mo) must conform with EPA regulations governing
storage, transportation, treatment, and waste disposal.
Check Digit Verification of cas no
The CAS Registry Mumber 4549-40-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,5,4 and 9 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4549-40:
(6*4)+(5*5)+(4*4)+(3*9)+(2*4)+(1*0)=100
100 % 10 = 0
So 4549-40-0 is a valid CAS Registry Number.
InChI:InChI=1/C3H6N2O/c1-3-5(2)4-6/h3H,1H2,2H3
4549-40-0Relevant articles and documents
Base-Induced Fragmentation of β-Hydroxy Nitrosamines
Loeppky, R. N.,McKinley, W. A.,Hazlitt, L. G.,Outram, J. R.
, p. 4833 - 4841 (2007/10/02)
β-Hydroxy nitrosamines have been found to undergo a base-induced fragmentation reaction.The reaction cleaves the Cα-Cβ bond of the substrate to produce an aldehyde or ketone and a smaller alkylnitrosamine.Rate contants for the fragmentation induced by potassium tert-butoxide in THF or tert-butyl alcohol have been measured for nine substrates at temperatures between 35 and 70 deg C.The rate constants are a function of base concentration and range between 0.15x10-6 and 308x10-6 s-1.Rate constants have been determined for (2-hydroxyethyl)methylnitrosamine,N-nitrosodiethanolamine, (2-hydroxy-2-methylpropyl)methylnitrosamine, (2-hydroxy-2-phenylethyl)methylnitrosamine, N-nitrosoephedrine, (2-hydroxy-2,2-diphenylethyl)methylnitrosamine, and (2-hydroxy-2-phenylpropyl)methylnitrosamine.The nitrosamino alcohol fragmentation rates are in the order tertiary > secondary > primary, and the rate appears to be a function of product stability and steric strain in the substrate.A mechanism which accounts for these observations is proposed.
