455-20-9

Usage

Uses

Used in Organic Synthesis:
p-Ethylbenzenesulphonyl fluoride is used as a reagent for the introduction of the sulphonyl fluoride functional group into organic molecules, facilitating the synthesis of various compounds.
Used in Pharmaceutical and Agrochemical Preparation:
p-ethylbenzenesulphonyl fluoride is utilized in the preparation of pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides.
Used in Synthesis of Functional Materials:
p-Ethylbenzenesulphonyl fluoride is employed in the synthesis of other functional materials, expanding its applications in material science.
Used in Bioconjugation and Chemical Biology Applications:
It has been investigated for its potential use as a reagent in bioconjugation and chemical biology, indicating its potential in the development of novel biological tools and techniques.

InChI:InChI=1/C8H9FO2S/c1-2-7-3-5-8(6-4-7)12(9,10)11/h3-6H,2H2,1H3

Upstream product

• 100-41-4 ethylbenzene 
• 53661-18-0 p-ethylphenylhydrazine hydrochloride 
• 52436-73-4 4-ethylbenzenediazonium tetrafluoroborate 

Downstream Products

• 93728-31-5 bis-(4-ethyl-benzenesulfonyl)-methane 
• 19164-75-1 1-benzenesulfonyl-4-ethylbenzene 
• 433-21-6 4-(2-bromoacetyl)benzene-1-sulfonyl fluoride 
• 75177-14-9 4-acetylbenzenesulfonyl azide 
• 322-14-5 4-[(1RS,2RS)-2-(2.2-dichloro-acetylamino)-1.3-dihydroxy-propyl]-benzenesulfonyl fluoride 
• 345-84-6 4-(N-dichloroacetyl-seryl)-benzenesulfonyl fluoride 
• 322-31-6 4-dibromoacetyl-benzenesulfonyl fluoride 
• 100958-92-7 4-bromoacetyl-benzenesulfonyl azide 
• 456-11-1 4-(N-dichloroacetyl-glycyl)-benzenesulfonyl fluoride 

Relevant academic research and scientific papers

Copper-catalyzed three-component reaction of arylhydrazine hydrochloride, DABSO, and NFSI for the synthesis of arenesulfonyl fluorides

This paper reports a convenient copper-catalyzed three-component conversion of arylhydrazine hydrochlorides to arenesulfonyl fluorides in good yields under mild conditions, using 1,4-diazabicyclo [2.2.2]octane bis(sulfur dioxide) (DABSO) as a sulfonyl source andN-fluorobenzenesulfonimide (NFSI) as a fluorine source based on a radical sulfur dioxide insertion and fluorination strategy. Notably, arylhydrazine hydrochloride is used as a safe precursor of aryl radicals.

Visible-Light-Mediated Synthesis of Sulfonyl Fluorides from Arylazo Sulfones

Sulfonyl fluorides are useful motifs for a wide range of applications in organic synthesis including sulfur (VI) fluoride exchange-based “click chemistry.” Herein, a visible-light-mediated synthesis of sulfonyl fluorides from arylazo sulfones is described. In the present study, K2S2O5 and N-fluorobenzenesulfonimide (NFSI) were used as the sulfonyl source and fluorinating agent, respectively, for visible-light-mediated fluorosulfonylation of arylazo sulfones to prepare various sulfonyl fluorides in 60–85% yield. This protocol is a synthetic approach to provide useful sulfonyl fluoride structures at room temperature. (Figure presented.).