455-84-5

Basic information

• Product Name: 4-FLUORO-3-METHYLBENZOYL CHLORIDE
• Synonyms: 4-FLUORO-M-TOLUOYL CHLORIDE;4-FLUORO-3-METHYLBENZOYL CHLORIDE;4-Fluoro-3-methylbenzoyl chloride, 97+%;4-Fluoro-3-methylbenzoyl;4-Fluoro-3-methylbenzoyl chloride 98%;4-Fluoro-3-methylbenzoylchloride98%;5-(Chlorocarbonyl)-2-fluorotoluene
• CAS NO: 455-84-5
• Molecular Formula: C₈H₆ClFO
• Molecular Weight: 172.58
• EINECS: -0
• Product Categories: Acid Halides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 455-84-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 129-133 °C17 mm Hg(lit.)
• Flash Point: 208 °F
• Appearance: /
• Density: 1.215 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.158mmHg at 25°C
• Refractive Index: n20/D 1.5320(lit.)
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), DMSO (Sparingly)
• Sensitive: Moisture Sensitive
• Stability: Moisture Sensitive
• BRN: 1936532
• CAS DataBase Reference: 4-FLUORO-3-METHYLBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-3-METHYLBENZOYL CHLORIDE(455-84-5)
• EPA Substance Registry System: 4-FLUORO-3-METHYLBENZOYL CHLORIDE(455-84-5)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45-27
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• TSCA: N
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 455-84-5(Hazardous Substances Data)

Usage

Uses

4-Fluoro-3-methylbenzoyl Chloride can be used as medicinal compositions as p38MAP kinases and/or TNF-α production inhibitor for pain.

InChI:InChI=1/C8H6ClFO/c1-5-4-6(8(9)11)2-3-7(5)10/h2-4H,1H3

Upstream product

• 403-15-6 4-fluoro-3-methyl-benzoic acid 

Downstream Products

• 95729-13-8 N-(3,5-Dichloro-pyridin-2-yl)-4-fluoro-3-methyl-benzamide 
• 834895-47-5 3-(3-methoxy-4-pyrrolidinophenyl)-3-phenyl-3H-naphtho[2,1-b]pyran 
• 834895-46-4 3-(3-methyl-4-pyrrolidinophenyl)-3-phenyl-3H-naphtho[2,1-b]pyran 
• 834895-60-2 1-(3-methyl-4-pyrrolidinophenyl)-1-phenylprop-2-yn-1-ol 
• 834895-54-4 3-methyl-4-pyrrolidinobenzophenone 
• 345-66-4 (4-fluoro-3-methylphenyl)(phenyl)methanone 
• 1027169-07-8 (R)-2-(4-Fluoro-3-methyl-benzoylamino)-3-hydroxy-propionic acid methyl ester 
• 95729-14-9 N-(2,4-Dichloro-phenyl)-4-fluoro-3-methyl-benzamide 
• 348167-03-3 3,5-Dibromo-4-[2-(4-fluoro-3-methylbenzoyl)-5-isopropyl-4-methoxyphenoxy]phenylacetic acid methyl ester 

Relevant articles and documents

Palladium-Catalyzed C-H Trifluoroethoxylation of N-Sulfonylbenzamides

The trifluoroethyl aryl ethers are important motifs in drug molecules. However, a report devoted specifically to the study of transition-metal-catalyzed C-H trifluoroethoxylation has not been reported to date. A protocol of Pd(II)-catalyzed o-C-H trifluor

1,2,4 -TRIAZOLES AS ALLOSTERIC MODULATORS OF MGLU5 RECEPTOR ACTIVITY FOR THE TREATMENT OF SCHIZOPHRENIA OF DEMENTIA

This invention relates to compounds of formula (I) their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, X, R1, R2, R3 have meanings given in the description.

New carboxylic acid amides, the preparation thereof and their use as medicaments

The present invention relates to new substituted carboxylic acid amides of general formula wherein A, B and R1 to R5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.