45506-41-0

Usage

Uses

Used in Pharmaceutical Industry:
2-Piperidinol is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new medications and enhance existing ones.
Used in Agrochemical Industry:
2-Piperidinol is used as an intermediate in the production of agrochemicals, playing a role in the creation of compounds that protect crops and enhance agricultural productivity.
Used in Organic Compounds Synthesis:
2-Piperidinol is used as an intermediate in the synthesis of other organic compounds, contributing to the development of a wide range of chemical products.
Used as a Laboratory Solvent:
2-Piperidinol is used as a solvent in laboratory research, facilitating various chemical reactions and processes.
Used as a Laboratory Reagent:
2-Piperidinol is used as a reagent in laboratory research, aiding in the analysis and synthesis of different chemical substances.
Used in Therapeutic Research:
2-Piperidinol is studied for its potential as a therapeutic agent in the treatment of neurological and psychiatric disorders, highlighting its possible applications in medicine.
Used as a Precursor in Drug and Chemical Production:
2-Piperidinol is utilized as a precursor in the production of various drugs and chemicals, indicating its importance in the synthesis of a broad spectrum of substances.

InChI:InChI=1/C5H11NO.ClH/c7-5-3-1-2-4-6-5;/h5-7H,1-4H2;1H

Synthetic route

Cyclopentanone oxime (1192-28-5) → 2-hydroxy piperidine (45506-41-0)

Conditions	Yield
Multi-step reaction with 2 steps 1: thionyl chloride / dichloromethane / 6 h / 30 - 35 °C 2: cobalt(II) acetate; sodium tetrahydroborate / water / 12 h / 15 - 25 °C View Scheme

piperidin-2-one (675-20-7) → 2-hydroxy piperidine (45506-41-0)

Conditions	Yield
With sodium tetrahydroborate; cobalt(II) acetate In water at 15 - 25℃; for 12h;

cyclopentanone (120-92-3) → 2-hydroxy piperidine (45506-41-0)

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium hydroxide; hydroxylamine hydrochloride / water / 3.5 h / 20 - 30 °C 2: thionyl chloride / dichloromethane / 6 h / 30 - 35 °C 3: cobalt(II) acetate; sodium tetrahydroborate / water / 12 h / 15 - 25 °C View Scheme

2-hydroxy piperidine (45506-41-0) → 2-piperideine (37497-65-7)

Conditions	Yield
With ammonium chloride at 15 - 25℃; for 5h;	91.19%

2-hydroxy piperidine (45506-41-0) → (2-oxopiperidine-1-yl)chlorobenzene

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydrogensulfite; sulfuric acid / 230 °C / 20252 Torr 2: sulfuric acid; iron(III) chloride / water View Scheme

2-hydroxy piperidine (45506-41-0) → ethyl 7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazole[3,4-c]pyridine-3-carboxylate

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium hydrogensulfite; sulfuric acid / 230 °C / 20252 Torr 2: sulfuric acid; iron(III) chloride / water 3: sodium hydroxide / butan-1-ol / 120 °C View Scheme

2-hydroxy piperidine (45506-41-0) → 7-oxo-6-[4-(2-oxopiperidine-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazole[3,4-c]pyridine-3-carboxylic acid

Conditions	Yield
Multi-step reaction with 4 steps 1: sodium hydrogensulfite; sulfuric acid / 230 °C / 20252 Torr 2: sulfuric acid; iron(III) chloride / water 3: sodium hydroxide / butan-1-ol / 120 °C 4: sodium hydroxide / water; methanol / Reflux View Scheme

Upstream product

• 120-92-3 cyclopentanone 
• 675-20-7 piperidin-2-one 
• 1192-28-5 Cyclopentanone oxime 

Downstream Products

• 2402-77-9 2,3-dichloro-pyridine 
• 27471-37-0 (2-oxopiperidine-1-yl)chlorobenzene 

Relevant academic research and scientific papers

Synthetic method 2-3 -dichloropyridine (by machine translation)

The invention provides 2-3 -dichloropyridine synthesis method which comprises the following steps: reacting cyclopentanone with hydroxylamine hydrochloride to obtain compound A; compound A under the action of ammonium chloride to obtain compound C; compound C under the action of ammonium chloride to obtain compound D; compound E reacts with chlorine to obtain compound E; compound E and tert-butylphosphinic acid ester are reacted to obtain 2, 3 - dichloropyridines. The method has the advantages of simple operation steps, cheap and easily available reaction raw materials, 68.88%% of total molar yield, 2 or more purity 3 - 98.0% -dichloropyridine, and good product quality, and is suitable for industrial production. (by machine translation)