45514-40-7Relevant academic research and scientific papers
Efficient synthesis of sulfonylguanidines via reaction of tetra-substituted urine with ArSO2NCO
Han, Jianjie,Zhou, Rongyan,Huang, Chao,Zeng, Qingkai,Long, Qiumeng,Zhang, Qianjun,Cong, Hang,Zhou, Qingdi,Wei, Gang,Liu, Mao
supporting information, (2019/11/11)
An efficient synthesis of sulfonylguanidines via reaction of tetra-substituted urines with ArSO2NCO has been developed with good yields, which provides a convenient way for synthesis of sulfonyl group protected guanidine from urine in one step.
3,4-difluorobenzonitrile preparation method
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Paragraph 0039; 0040; 0041, (2018/09/11)
The invention discloses a 3,4-difluorobenzonitrile preparation method. The 3,4-difluorobenzonitrile preparation method comprises the following steps of taking 3,4-difluorobenzonitrile as a raw material, potassium fluoride as a fluorinated reagent and bis-(N,N'-1,3-dimethyl-2-imidazolinyl)-chloride ammonium salt as a phase transfer catalyst, then adding a reducing agent and a dispersant, and performing reaction to prepare the 3,4-difluorobenzonitrile. In the method, the temperature of fluorination reaction is relatively low, the reaction time is short, the total molar yield can reach about 90 percent, and the solvents and the catalyst can be recycled; produced potassium chloride in reaction becomes a pure product with the purity being 99 percent or above after recrystallization, and the pure product can be directly sold, so that the production cost is reduced; in addition, the technology is safe and environmentally friendly, is small in quantities of three wastes (waste water, waste solid and waste gas) and is suitable for industrial production.
Experimental Basicities of Superbasic Phosphonium Ylides and Phosphazenes
Saame, Jaan,Rodima, Toomas,Tshepelevitsh, Sofja,Kütt, Agnes,Kaljurand, Ivari,Haljasorg, T?iv,Koppel, Ilmar A.,Leito, Ivo
, p. 7349 - 7361 (2016/09/09)
Experimental basicities of some of the strongest superbases ever measured (phosphonium ylides) are reported, and by employing these compounds, the experimental self-consistent basicity scale of superbases in THF, reaching a pKα (estimate of pKa) of 35 and spanning more than 30 pKa units, has been compiled. Basicities of 47 compounds (around half of which are newly synthesized) are included. The solution basicity of the well-known t-Bu-N=P4(dma)9 phosphazene superbase is now rigorously linked to the scale. The compiled scale is a useful tool for further basicity studies in THF as well as in other solvents, in particular, in acetonitrile. A good correlation between basicities in THF and acetonitrile spanning 25 orders of magnitude gives access to experimentally supported very high (pKa > 40) basicities in acetonitrile, which cannot be directly measured. Analysis of structure-basicity trends is presented.
Conformational and Tautomeric Studies of Acylguanidines. Part 1. Synthesis, Ultraviolet Spectroscopy, Tautomeric Preference, and Site of Protonation in Some Model Compounds
Greenhill, John V.,Ismail, Jamil M.,Edwards, Philip N.,Taylor, Peter J.
, p. 1255 - 1264 (2007/10/02)
Six of the possible acylguanidine conformers have been prepared as model compounds in fixed form; all protonate on the imino nitrogen.The expected close u.v. resemblance between the cations is found for the major band near 200 nm but there are complicatio
Diaza-cyclic derivatives of guanidine
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, (2008/06/13)
5-Membered 1,3-diazacarbocyclic derivatives of guanidine having hypoglycemic activity.
