45521-08-2

Basic information

• Product Name: (S)-Oxazolidine-4-carboxylic acid
• Synonyms: (S)-Oxazolidine-4-carboxylic acid
• CAS NO: 45521-08-2
• Molecular Formula: C₄H₇NO₃
• Molecular Weight: 117.103
• Mol File: 45521-08-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 295℃
• Flash Point: 132℃
• Appearance: /
• Density: 1.330
• CAS DataBase Reference: (S)-Oxazolidine-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-Oxazolidine-4-carboxylic acid(45521-08-2)
• EPA Substance Registry System: (S)-Oxazolidine-4-carboxylic acid(45521-08-2)

Safety Data

• Hazardous Substances Data: 45521-08-2(Hazardous Substances Data)

Usage

General Description

(S)-Oxazolidine-4-carboxylic acid is a chemical compound with the molecular formula C4H7NO3. It is a derivative of the heterocyclic compound oxazolidine and contains a carboxylic acid functional group. (S)-Oxazolidine-4-carboxylic acid is commonly used in the production of pharmaceuticals and agrochemicals, as well as in organic synthesis as a chiral building block. Its stereochemistry plays a crucial role in its biological, chemical, and medicinal properties. (S)-Oxazolidine-4-carboxylic acid has been studied for its potential anti-infective and anti-inflammatory activities, and its versatility makes it a valuable tool in both academic and industrial research.

Upstream product

• 161979-35-7 (S)-3-(tert-butoxycarbonyl)-1,3-oxazolidine-4-carboxylic acid 
• 50-00-0 formaldehyd 
• 56-45-1 L-serin 

Downstream Products

• 97534-82-2 (4S)-3-[(benzyloxy)carbonyl]-1,3-oxazolidine-4-carboxylic acid 
• 380149-71-3 Fmoc-Tyr(All)-Ser(Ψ^H,Hpro)-OH 
• 162061-70-3 (4S)-N-benzoyl-1,3-oxazolidine-4-carboxylic acid 

Relevant articles and documents

Synthesis of (R)-2-amino-3-(xenyl-4-yl)-1-propyl alcohol

The invention relates to a preparation method of (R)-2-amino-3-(xenyl-4-yl)-1-propyl alcohol. The (R)-2-amino-3-(xenyl-4-yl)-1-propyl alcohol is prepared from a compound having a general formula (B) through ring opening reaction, wherein R1 is defined as a hydrogen atom, or a linear alkyl, or a branched alkyl, or a cyclopropyl, or a cyclobutyl, or a cyclopentyl, or a cyclohexyl, or a cycloheptyl. According to the preparation method described by the invention, the reaction condition is mild, less by-products are generated, the operation is simple and convenient, the quality of each intermediate related is controllable, and the (R)-2-amino-3-(xenyl-4-yl)-1-propyl alcohol prepared by the synthetic process has the advantages of lower cost, better product quality, fewer three wastes and a higher industrialized process degree. (The (R)-2-amino-3-(xenyl-4-yl)-1-propyl alcohol has the structural general formula shown in the specification).

Highly efficient small organic molecules for enantioselective direct aldol reaction in organic and aqueous media

(Chemical Equation Presented) A series of highly efficient organocatalysts have been derived from naturally available amino acids for carrying out enantioselective direct aldol reaction in both organic and aqueous medium. The aldol products were obtained in high diastereoselectivities (up to 99:1) and enantioselectivities (up to >99% ee) for a broader range of substrates using 1 mol % of a catalyst. The results demonstrate that the structural features of organocatalysts play a crucial role in obtaining high optical purity of aldol adducts in an aqueous medium. Further, the role of water in increasing the rate and enantioselectivity of the reaction has been illustrated. Moreover, the aldol products have been employed in the synthesis of chiral amino alcohols which act as useful intermediates for building up complex natural products.

Zinc borohydride reduction of α-amino ketones: A highly diastereoselective synthetic route to anti-γ-hydroxy-β-amino alcohols

A highly diastereoselective synthesis of anti-γ-hydroxy β-amino alcohols via Zn(BH4)2 reductions of serine derived α-amino ketones is described. The latter were prepared from a serine derived γ-amino-β-ketosulfone via a α-alkylation-