455256-35-6

Usage

Uses

Used in Organic Synthesis:
(AzidoMethyl)-cyclopentane is used as a building block for the synthesis of various organic compounds. Its unique structure, featuring a cyclopentane ring and a reactive azide group, allows for the creation of a wide range of functionalized cyclopentane derivatives.
Used in Pharmaceutical Industry:
(AzidoMethyl)-cyclopentane is used as a precursor for the development of pharmaceutical compounds. The reactivity of the azide group enables the formation of new bonds and the synthesis of complex molecules with potential therapeutic applications.
Used in Chemical Research:
(AzidoMethyl)-cyclopentane is utilized as a research tool in the field of chemistry, particularly in the study of reaction mechanisms and the development of new synthetic methods. Its high reactivity and unique structure make it an interesting subject for scientific investigation.
Used in Material Science:
(AzidoMethyl)-cyclopentane can be employed in the development of novel materials, such as polymers and composites, with specific properties. The azide group's reactivity allows for the creation of new linkages and the modification of material characteristics.
Safety Precautions:
Due to the explosive nature of (AzidoMethyl)-cyclopentane, it is crucial to follow proper safety measures when handling (AzidoMethyl)-cyclopentane. This includes using appropriate protective equipment, working in a well-ventilated area, and adhering to established laboratory safety protocols.

Upstream product

• 3814-30-0 cyclopentylmethyl bromide 
• 73017-76-2 methanesulfonic acid cyclopentylmethyl ester 
• 21856-53-1 toluene-4-sulphonic acid cyclopentylmethyl ester 
• 3637-61-4 1-amino-cyclopentanemethanol 

Relevant academic research and scientific papers

P-benzoquinone diazide core skeleton derivative as well as preparation method and application thereof

The invention relates to a p-benzoquinone diazide core skeleton derivative and a preparation method and application, thereof, belongs to. the field of organic chemistry, and can effectively treat-ovarian-ovarian cancer-carcinoma STAT3-ovarian, cancer-ATG4

Using the same hydroxamic acid derivative and HDAC8 inhibitor (by machine translation)

Disclosed are: a compound which is capable of inhibiting the function of HDAC8; and an HDAC8 inhibitor. Specifically disclosed is a hydroxamic acid derivative which is characterized by being composed of a compound represented by general formula (1) (wherein X represents an aromatic substituent or an optionally substituted 3-8 membered ring, and n represents an integer of 0-20), or a pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof.

SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF

Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of conditions such as depression and related disorders. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries

To find HDAC8-selective inhibitors, we designed a library of HDAC inhibitor candidates, each containing a zinc-binding group that coordinates with the active-site zinc ion, linked via a triazole moiety to a capping structure that interacts with residues on the rim of the active site. These compounds were synthesized by using click chemistry. Screening identified HDAC8-selective inhibitors including C149 (IC50 = 0.070 μM), which was more potent than PCI-34058 (6) (IC50 = 0.31 μM), a known HDAC8 inhibitor. Molecular modeling suggested that the phenylthiomethyl group of C149 binds to a unique hydrophobic pocket of HDAC8, and the orientation of the phenylthiomethyl and hydroxamate moieties (fixed by the triazole moiety) is important for the potency and selectivity. The inhibitors caused selective acetylation of cohesin in cells and exerted growth-inhibitory effects on T-cell lymphoma and neuroblastoma cells (GI50 = 3-80 μM). These findings suggest that HDAC8-selective inhibitors have potential as anticancer agents.

An unexpected example of protein-templated click chemistry

(Figure Presented) It all happened with a click: In a search for histone deacetylase (HDAC) inhibitors using in situ click chemistry, the first example of protein-Cu acceleration of the azide-alkyne cycloaddition reaction was uncovered. The copper center

(2-hydroxy)ethyl-thioureas useful as modulators of alpha2B adrenergic receptors

Compounds of formula (i) and of formula (ii) wherein the symbols have the meaning disclosed in the specification, specifically or selectively modulate α2B and/or α2C adrenergic receptors in preference over α2A adrenergic receptors, and as such are useful for alleviating chronic pain and allodynia and have no or only minimal cardivascular and/or sedatory activity.