455259-86-6

Basic information

• Product Name: Urea, N-(3-cyanophenyl)-N'-[6-[[4-[(4-fluorophenyl)methyl]-1-piperidinyl]methyl ]-1,3-benzodioxol-5-yl]-
• CAS NO: 455259-86-6
• Molecular Formula: C28H27FN4O3
• Molecular Weight: 486.546
• Mol File: 455259-86-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Urea, N-(3-cyanophenyl)-N'-[6-[[4-[(4-fluorophenyl)methyl]-1-piperidinyl]methyl ]-1,3-benzodioxol-5-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Urea, N-(3-cyanophenyl)-N'-[6-[[4-[(4-fluorophenyl)methyl]-1-piperidinyl]methyl ]-1,3-benzodioxol-5-yl]-(455259-86-6)
• EPA Substance Registry System: Urea, N-(3-cyanophenyl)-N'-[6-[[4-[(4-fluorophenyl)methyl]-1-piperidinyl]methyl ]-1,3-benzodioxol-5-yl]-(455259-86-6)

Safety Data

• Hazardous Substances Data: 455259-86-6(Hazardous Substances Data)

Upstream product

• 16413-26-6 3-cyanophenyl isocyanate 
• 455259-96-8 methanesulfonic acid 6-nitro-benzo[1,3]dioxol-5-ylmethyl ester 
• 92822-02-1 4-(4-fluorobenzyl)piperidine 

Relevant articles and documents

Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists

Structure-activity relationship (SAR) studies of initial screening hits from our corporate library of compounds and a structurally related series of CCR1 receptor antagonists were used to determine that an N-(alkyl)benzylpiperidine is an essential pharmacophore for selective CCR3 antagonists. Further SAR studies that introduced N-(ureidoalkyl) substituents improved the binding potency of these compounds from the micromolar to the low nanomolar range. This new series of compounds also displays highly potent, in vitro functional CCR3-mediated antagonism of eotaxin-induced Ca2+ mobilization and chemotaxis of human eosinophils.