455281-26-2Relevant academic research and scientific papers
Synthesis of new ethyl 3-amino-4-arylfuran-2-carboxylates
Lisowski, Vincent,Vu, Duc Nghia,Feng, Xiao,Rault, Sylvain
, p. 753 - 756 (2002)
An efficient method for the preparation of new ethyl 3-amino-4-arylfuran-2-carboxylates is described. The synthesis proceeds via the corresponding hydroxyacrylonitrile sodium salt and an intermediate malonate vinyl ether. The last step of ring closure aff
Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1-5, GSK-3) inhibitors
Rochais, Christophe,Duc, Nghia Vu,Lescot, Elodie,Sopkova-de Oliveira Santos, Jana,Bureau, Ronan,Meijer, Laurent,Dallemagne, Patrick,Rault, Sylvain
scheme or table, p. 708 - 716 (2009/09/05)
We herein describe the synthesis of novel dipyrrolo- and furopyrrolopyrazinones related to highly cytotoxic tripentones and to their oximes. The synthetic pathway involved in particular a Curtius rearrangement and a subsequent cyclisation into the title p
The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors
Tumey, L. Nathan,Bom, David,Huck, Bayard,Gleason, Elizabeth,Wang, Jianmin,Silver, Daniel,Brunden, Kurt,Boozer, Sherry,Rundlett, Stephen,Sherf, Bruce,Murphy, Steven,Dent, Tom,Leventhal, Christina,Bailey, Andrew,Harrington, John,Bennani, Youssef L.
, p. 277 - 281 (2007/10/03)
We describe the identification and SAR of a series of low nanomolar inhibitors of FEN1, an enzyme involved in DNA repair pathways. These inhibitors have been shown to sensitize certain cell lines to DNA damage. Flap endonuclease-1 (FEN1) is a key enzyme i
