45533-49-1

Upstream product

• 78-82-0 Isobutyronitrile 
• 60-23-1 Cysteamine 
• 547-63-7 Methyl isobutyrate 
• 156-57-0 2-mercaptoethylamine hydrochloride 
• 24050-11-1 2-isopropyl-1,3-thiazolidine 
• 81563-10-2 (Z)-3-(2-Amino-ethylsulfanyl)-4-methyl-pent-2-enenitrile 
• 6282-73-1 N-(2-hydroxyethyl)isobutyramide 

Downstream Products

• 55089-28-6 2-(1,1-dimethyl-2-phenyl-ethyl)-4,5-dihydro-thiazole 
• 13146-74-2 8a-Isopropyl-5,7-dioxo-2,3,5,6,7,8,8a-heptahydro-thiazolo<3,2-a>-s-triazin 

Relevant academic research and scientific papers

Microwave-Assisted Synthesis of 2-Substituted 2-Thiazolines and 5,6-Dihydro-4 H -1,3-thiazines

An efficient and general method for the synthesis of 2-substituted thiazolines and 5,6-dihydro-4 H -1,3-thiazines is developed via microwave-assisted ring closure of ω-thioamidoalcohols promoted by ethyl polyphosphate (PPE). The cyclization reaction involves an S N 2-type mechanism and features the advantages of very short reaction times, high yields and a predictable stereochemical outcome. The acyclic precursors are prepared in high overall yields by an improved diacylation-thionation-saponification sequence from commercially available ω-amino alcohols. The whole process is metal-free and operationally simple.

Syntheses of 2-isopropyl-4,5-dihydrothiazole and 6-hydroxy-6-methyl-3- heptanone, pheromone components of the male mouse, Mus musculus

Syntheses of 2-isopropyl-4,5-dihydrothiazole and 6-hydroxy-6-methyl-3- heptanone, pheromone components of the male mouse, Mus musculus, were achieved to provide sufficient amounts of samples for biological studies.

Novel synthesis of 2-thiazolines

The synthesis of a series of 2-thiazolines was carried out under mild conditions from the corresponding thiazolidines, by a Ru-catalyzed/TBHP oxidation reaction conditions. The reaction was chemoselective towards the amine-imine oxidation and was also regioselective, affording the unsaturation at the 2-position of the heterocycle, even with thiazolidine substrates bearing ester groups at the 4-position. (C) 2000 Elsevier Science Ltd.

Synthetic studies of thiazoline and thiazolidine-containing natural products - 1. Phosphorus pentachloride-mediated thiazoline construction reaction

Phosphorus pentachloride effectively mediates the cyclization of N- acylcysteamine derivatives giving rise to thiazoline rings. Using this method, sterically hindered thiazoline analogs could be constructed and thus segment A (the left half) of micacocidin, a unique antimycoplasma antibiotic, was synthesized efficiently.

Research on radioprotective agents: Δ-2 Thiazolines and homologous derivatives

Compounds derived from Δ-2 thiazoline, Δ-2 thiazolinium iodoalkylate and 4,5-dihydro-1,3 thiazine have been prepared and evaluated as potential antiradiation agents in mice. They generally have a low toxicity and significant radioprotective activity.

ALLENES-41. THE ADDITION OF THIOLS TO ALLENYL- AND PHENYLPROPYNYLNITRILE AND THE FORMATION OF THIAZOLINES AND BENZOTHIAZOLES

Thiols add to allenylnitriles to give unconjugated nitriles which may be isomerised to conjugated enesulphide nitriles either at high temperature (200o) or with base.Phenylpropynenitrile gives conjugated adducts directly.Heating the conjugated adducts from aminoethanethiols at >200o results in 5-exotrig ring closure and elimination of acetonitrile to give thiazolines and benzothiazoles.