455333-79-6

Basic information

• Product Name: Glycine, N-[(4-nitrophenyl)sulfonyl]-N-2-propenyl-, ethyl ester
• CAS NO: 455333-79-6
• Molecular Formula: C13H16N2O6S
• Molecular Weight: 328.346
• Mol File: 455333-79-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Glycine, N-[(4-nitrophenyl)sulfonyl]-N-2-propenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-[(4-nitrophenyl)sulfonyl]-N-2-propenyl-, ethyl ester(455333-79-6)
• EPA Substance Registry System: Glycine, N-[(4-nitrophenyl)sulfonyl]-N-2-propenyl-, ethyl ester(455333-79-6)

Safety Data

• Hazardous Substances Data: 455333-79-6(Hazardous Substances Data)

Upstream product

• 99069-33-7 ethyl 2-(4-nitrobenzenesulfonylamido)acetate 
• 106-95-6 allyl bromide 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 

Downstream Products

• 3182-79-4 N-allylglycine ethyl ester 

Relevant articles and documents

A general approach to dehydro-Freidinger lactams: Ex-chiral pool synthesis and spectroscopic evaluation as potential reverse turn inducers

Starting from natural α-amino acids, a practical synthesis of the dehydro-Freidinger lactams 9a-h based on the ring-closing olefin metathesis reaction was investigated. The presented examples comprise 6-, 7-, 8-, 9-, and 10-membered cyclic dipeptide mimics. Structural variations were demonstrated. We approached the metathesis precursors 8a-h employing an N-alkylation/peptide-coupling strategy. Subsequent ring closure was promoted by the ruthenium-based catalyst 10a or 10b. The resulting tetraresidue 11d was shown to undergo intramolecular hydrogen bonding based on NMR and FT-IR studies. Thus, the development of dehydro-Freidinger lactams as potential reverse turn inducers stabilizing an intramolecular NHi+3...COi hydrogen-bond was demonstrated.