455927-19-2Relevant academic research and scientific papers
Synthesis, characterization, anticancer activity, and QSAR-studies of some new tetrahydropyrimidines
Desai,Chhabaria,Dodiya, Amit,Bhavsar, Ajit M.,Baldaniya
experimental part, p. 1331 - 1339 (2012/05/05)
Several new substituted 1,2,3,4 tetrahydropyrimidine derivatives have been synthesized and evaluated for their in vitro anticancer activity on various cell lines. Some of the molecules have exhibited significantly potent inhibition on several cell lines. To find out inter correlation between anticancer activity and molecular descriptors, QSAR study was carried out. Molecular descriptors used for the study were ClogP (lipophilic), CMR (steric), and polarity (electronic). Anticancer activity is expressed in the form of LogGI 50+. Activity on different cell lines was independently correlated with molecular descriptors. On the basis of the results, significant correlation between anticancer activity on some of the cell lines and molecular descriptor was observed. Springer Science+Business Media, LLC 2010.
