455948-99-9

Upstream product

• 107-30-2 chloromethyl methyl ether 
• 455948-88-6 (4R,5S)-3-[(2R,3S,4S)-3-hydroxy-2,4-dimethylhept-6-enoyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one 
• 5673-98-3 (S)-(-)-2-methyl-4-penten-1-ol 
• 61866-32-8 (S)-2-methyl-4-pentenal 

Downstream Products

• 750646-36-7 (4R,5S)-3-((2R,3S,6S,7S,8S)-3,9-Dihydroxy-7-methoxymethoxy-2,6,8-trimethyl-nonanoyl)-4-methyl-5-phenyl-oxazolidin-2-one 
• 455948-95-5 (5S,6S)-6-[(1S,4S,5R,6R)-6-(tert-butyldiphenylsilyloxy)-4-hydroxy-1,5-dimethyl-oct-7-ynyl]-5-methyl-5,6-dihydro-pyran-2-one 
• 455949-04-9 (2R,3S,4S,7S,8R,9R)-9-(tert-Butyl-diphenyl-silanyloxy)-3,7-bis-methoxymethoxy-2,4,8-trimethyl-undec-10-ynal 
• 455948-90-0 (4R,5S)-3-[(2R,3S,6S,7S,8S)-9-(tert-butyldimethylsilyloxy)-3-hydroxy-7-methoxymethoxy-2,6,8-trimethyl-nonanoyl]-4-methyl-5-phenyl-oxazolidin-2-one 
• 455948-93-3 (2S,3S,4S,7S,8R,9R)-9-(tert-butyldiphenylsilyloxy)-3,7-bis-methoxymethoxy-2,4,8-trimethyl-undec-10-yn-1-ol 
• 455948-94-4 methyl (4S,5S,6S,9S,10S,11R)-11-(tert-butyldiphenylsilyloxy)-5,9-bis(methoxymethoxy)-4,6,10-trimethyl-tridec-2-en-12-ynoate 
• 676254-81-2 (3R,4R,5S,8S,9S,10S)-11-(tert-butyldimethylsilyloxy)-3-(tert-butyldiphenylsilyloxy)-5,9-bis(methoxymethoxy)-4,8,10-trimethyl-undec-1-yne 
• 455949-05-0 Phosphoric acid (1S,2S,3R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-1-[(S)-3-((2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-butyl]-pent-4-ynyl ester bis-(9H-fluoren-9-ylmethyl) ester 

Relevant academic research and scientific papers

Determination of the relative configuration of the C-2-C-1′-fragment of cytostatin

Four diastereomers of a simple subtructure of cytostatin containing the α,β-unsaturated lactone subunit were synthesized and their NMR-spectroscopical data were compared with values recorded for the natural product in order to unravel the relative stereoc

Synthesis of the protein phosphatase 2A inhibitor (4S,5S,6S,10S,11S,12S)-cytostatin

Reagent-controlled reactions are key to the introduction of the stereocenters in the total synthesis of the cytostatin isomer 1. The stereochemical flexibility of the synthesis allows efficient and convenient access to other isomers.