45644-21-1

Basic information

• Product Name: 2-Amino-6-chloropyridine
• Synonyms: 2-CHLORO-6-AMINOPYRIDINE;2-AMINO-6-CHLOROPYRIDINE;6-CHLOROPYRIDIN-2-YLAMINE;6-CHLORO-2-PYRIDINAMINE;6-AMINO-2-CHLOROPYRIDINE;2-amino-6-chloro-pyridin;2-Pyridinamine,6-chloro-(9CI);2-CHIORO-6-AMINOPYRIDINE
• CAS NO: 45644-21-1
• Molecular Formula: C₅H₅ClN₂
• Molecular Weight: 128.56
• EINECS: -0
• Product Categories: PYRIDINE;pyridine derivative;Amines;Pyridines;Building Blocks;C5;C5 to C6;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;amine| alkyl chloride;Isoquinolines ,Heterocyclic Acids
• Mol File: 45644-21-1.mol
• Article Data: 19

Chemical Properties

• Melting Point: 69-73°C
• Boiling Point: 255.72 °C at 760 mmHg
• Flash Point: 108.456 °C
• Appearance: Orange to light brown/Powder or Low Melting Solid
• Density: 1.326 g/cm³
• Vapor Pressure: 0.016mmHg at 25°C
• Refractive Index: 1.607
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 2.76±0.24(Predicted)
• BRN: 108669
• CAS DataBase Reference: 2-Amino-6-chloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-6-chloropyridine(45644-21-1)
• EPA Substance Registry System: 2-Amino-6-chloropyridine(45644-21-1)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 26-36/37-36
• WGK Germany: 3
• RTECS: US1813350
• HazardClass: IRRITANT
• Hazardous Substances Data: 45644-21-1(Hazardous Substances Data)

Usage

Chemical Properties

White to light yellow powder

Uses

Different sources of media describe the Uses of 45644-21-1 differently. You can refer to the following data:
1. 2-Amino-6-chloropyridine used in a Ni(II)-catalyzed homo-coupling providing diamino-2,2′-bipyridine.
2. Substrate used in a Ni(II)-catalyzed homo-coupling providing diamino-2,2′-bipyridine.

InChI:InChI=1/C5H5ClN2/c6-4-2-1-3-5(7)8-4/h1-3H,(H2,7,8)

Upstream product

• 98130-68-8 6-chloro-pyridine-2-carbonyl azide 
• 20885-12-5 2-chloro-6-fluoropyridine 
• 94166-64-0 2-nitro-6-chloro-pyridine 
• 2402-78-0 2,6-dichloropyridine 
• 110-86-1 pyridine 
• 1075-62-3 N-(6-aminopyridin-2-yl)acetamide 
• 4684-94-0 6-chloropicolinic acid 
• 2402-95-1 2-chloropyridine-N-oxide 
• 909394-44-1 1-[(6-chloro-pyridin-2-yl)-hydrazonomethyl]-naphthalen-2-ol 
• 909394-43-0 2-{1-[(6-chloro-pyridin-2-yl)-hydrazono]-ethyl}-phenol 
• 909394-42-9 2-[(6-chloro-pyridin-2-yl)-hydrazonomethyl]-phenol 
• 909394-40-7 N-(6-chloro-pyridin-2-yl)-N'-thiophen-2-ylmethylene-hydrazine 
• 74405-06-4 3-(6-Chloro-pyridin-2-yl)-2,2-dimethyl-2,3-dihydro-benzo[e][1,3]oxazin-4-one 
• 159603-71-1 t-butyl N-(6-chloro-2-pyridinyl)carbamate 

Downstream Products

• 17920-35-3 2-amino-6-methoxypyridine 
• 86847-84-9 2,2-Dimethyl-N-(6-chloro-2-pyridinyl)propanamide 
• 63763-86-0 2-amino-6-N,N-dimethylamino pyridine 
• 110270-89-8 5-chloro-2-methylimidazo<1,2-a>pyridine hydrochloride 
• 76629-11-3 3-(6-chloro-2-pyridylimino)propionic acid 
• 83785-65-3 diethyl 2-(6-chloropyridin-2-yl)aminomethylenemalonate 
• 87779-02-0 2-chloromethyl-5-chloro-4H-pyrido<1,2-a>pyrimidin-4-one 
• 159603-71-1 t-butyl N-(6-chloro-2-pyridinyl)carbamate 
• 141454-59-3 2-chloro-N-(2-(6-chloro)pyridinyl)acetamide 
• 629617-11-4 N-(2-(1-(4-(2-methoxyphenyl)piperazinyl)ethyl))-N-(2-(6-chloro)pyridinyl)cyclohexane carboxamide 
• 86847-86-1 2,2-Dimethyl-N-<6-chloro-3-(methylthio)-2-pyridinyl>propanamide 
• 883987-26-6 2-amino-6-(2-methoxyethylamino)pyridine 
• 75135-46-5 2-Amino-6-methylaminopyridine 
• 442127-50-6 3-bromo-6-chloropyridin-2-amine 

Relevant articles and documents

Protein kinase inhibitor and use thereof

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Transition-metal-free access to 2-aminopyridine derivatives from 2-fluoropyridine and acetamidine hydrochloride

Under catalyst-free conditions, an efficient method for the synthesis of 2-aminopyridine derivatives through the nucleophilic substitution and hydrolysis of 2-fluoropyridine and acetamidine hydrochloride has been developed. This amination uses inexpensive acetamidine hydrochloride as the ammonia source and has the advantages of a high yield, high chemoselectivity and wide substrate adaptability. The results suggest that other N-heterocycles containing fluorine substituents can also complete the reaction via these reaction conditions and yield the target products.

Efficient reductions of various nitroarenes with scrap automobile catalyst and NaBH4

The effect of scrap automobile catalyst (SAC), a waste material, was investigated as a catalyst for the reduction of nitroarenes to the corresponding amines with sodium borohydride in aqueous ethanol at 5-25 °C. Along with the observed high conversions, the SAC and NaBH4 combination also exhibits a selectively catalyzed reduction in compounds containing other reducible functionalities, such as CN, Br, Cl and I. Recycling automobile wastes into a catalyst for organic reactions will offer both environmental protection and economic advantages. As a result, an effective, easy to use, low-priced and reliable method has been developed.