4565-29-1

Basic information

• Product Name: 5-ACETYL-2-THIOPHENECARBALDEHYDE
• Synonyms: 5-ACETYL-2-THIOPHENECARBALDEHYDE;5-ACETYL-2-THIOPHENECARBOXALDEHYDE;5-Acetyl-2-thiophenecarbaldehyde ,97%;5-Acetylthiophene-2-carbaldehyde;2-Acetyl-5-formylthiophene, 2-Ethanoyl-5-formylthiophene, 5-Acetyl-2-thenaldehyde;5-Formyl-2-acetylthiophene
• CAS NO: 4565-29-1
• Molecular Formula: C7H6O2S
• Molecular Weight: 154.19
• Mol File: 4565-29-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 104-105℃
• Boiling Point: 307.4 °C at 760 mmHg
• Flash Point: 139.7 °C
• Appearance: /
• Density: 1.262 g/cm³
• Vapor Pressure: 0.000726mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 5-ACETYL-2-THIOPHENECARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ACETYL-2-THIOPHENECARBALDEHYDE(4565-29-1)
• EPA Substance Registry System: 5-ACETYL-2-THIOPHENECARBALDEHYDE(4565-29-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36-36/37/38-20/21/22
• Safety Statements: 22-26-36/37/39
• RIDADR: 2811
• Hazardous Substances Data: 4565-29-1(Hazardous Substances Data)

Usage

Chemical Properties

Yellow solid

InChI:InChI=1/C7H6O2S/c1-5(9)7-3-2-6(4-8)10-7/h2-4H,1H3

Upstream product

• 5916-12-1 2-methyl-2-(thiophen-2-yl)-[1,3]dioxolane 
• 104208-17-5 2-(5-formyl-2-thienyl)-2-methyl-1,3-dioxolan 
• 88-15-3 2-Acetylthiophene 

Downstream Products

• 32411-15-7 1-(5-((dimethylamino)methyl)thiophen-2-yl)ethanone 
• 42791-51-5 2-acetyl-4-nitrothiophene 
• 692889-40-0 2-acetyl-4-amino-thiophene 

Relevant articles and documents

CHEMOSELECTIVE PROTECTION OF HETEROAROMATIC ALDEHYDES AS IMIDAZOLIDINE DERIVATIVES. PREPARATION OF 5-SUBSTITUTED FURAN- AND TIOPHENE-2-CARBOXALDEHYDES VIA METALLO-IMIDAZOLIDINE INTERMEDIATES

Furan-, tiophene- and N-methylpyrrole-2-carboxaldehydes may be transformed into the corresponding N,N'-dimethylimidazolidines in a reaction not requiring acid catalysis.The resulting furan and tiophene (but not N-methylpyrrole) derivatives may be metallated in high yields and the carboxaldehyde functionality regenerated under very mild conditions.Treatment of the aldehydoketone 2-acetyl-5-formylthiophene with N,N'-dimethylethylenediamine gives only the product of reaction at the aldehyde function thus establishing this methodology as a potentially valuable method for the protection of an aldehyde in the presence of a ketone.