457054-82-9Relevant academic research and scientific papers
Efficient macrocyclization by means of 2-nitrobenzenesulfonamide and total synthesis of lipogrammistin-A
Kan, Toshiyuki,Fujiwara, Akiko,Kobayashi, Hideki,Fukuyama, Tohru
, p. 6267 - 6276 (2007/10/03)
Synthesis of medium- and large-sized cyclic amines using alkylation with 2-nitrobenzenesulfonamides is described. Using either conventional alkylation procedures or Mitsunobu conditions, the cyclization reaction proceeded in a highly efficient manner. The usefulness of this methodology has been fully demonstrated in the total synthesis of lipogrammistin-A (9), an 18-membered cyclic polyamine.
Efficient synthesis of medium-sized cyclic amines by means of 2-nitrobenzenesulfonamide
Kan, Toshiyuki,Kobayashi, Hideki,Fukuyama, Tohru
, p. 697 - 699 (2007/10/03)
Construction of medium-sized cyclic amines using 2-nitrobenzenesulfonamides is described. Under either conventional alkylation or Mitsunobu reaction conditions, the cyclization reaction proceeded efficiently to give eight- to ten-membered rings.
