4574-75-8Relevant academic research and scientific papers
Facile and efficient synthesis of 4-alkyl derivatives of 3-carbamoyl- and 3,5-dicarbamoylpyridines as nicotinamide mimetics
Di Rienzo, Barbara,Mellini, Paolo,Tortorella, Silvano,De Vita, Daniela,Scipione, Luigi
experimental part, p. 3835 - 3838 (2011/01/12)
Nicotinamide plays a key role in many biological processes and, as a consequence, its derivatives could be attractive for the synthesis of biologically active compounds. Here a rapid and efficient way of preparing alkyl derivatives of nicotinamide, precisely, 4-alkyl-3-carbamoylpyridine and 4-alkyl-3,5-dicarbamoylpyridine is reported. The synthetic route developed adopts mild reaction conditions and produces target compounds in higher yields compared with methods described in literature. Georg Thieme Verlag Stuttgart · New York.
