457613-60-4Relevant academic research and scientific papers
Reaction of α,α-dibromo oxime ethers with Grignard reagents: Alkylative annulation providing a pyrimidine core
Kakiya, Hirotada,Yagi, Kazunari,Shinokubo, Hiroshi,Oshima, Koichiro
, p. 9032 - 9033 (2002)
A convergent synthesis of a pyrimidine core has been achieved. Treatment of α,α-dibromo oxime ethers, which are easily derived from the corresponding esters, with a variety of Grignard reagents provides trisubstituted pyrimidines in good yields. This new
Synthesis of pyrimidines via base-induced condensation of α-chloro oxime derivatives
Tsuritani, Takayuki,Shinokubo, Hiroshi,Oshima, Koichiro
, p. 122 - 123 (2007/10/03)
A facile synthesis of 2,4,6-trisubstituted pyrimidines from the reaction of α-chloro oxime ethers with Grignard reagents has been developed. Alkyl and aryl groups can be easily introduced at the 2-position of the pyrimidine core. In addition, a synthesis of unsymmetrical pyrimidines has been examined.
