457628-36-3

Usage

Uses

Used in Chemical Synthesis:
1,4-Difluoro-2-(prop-2-ynyloxy)benzene is used as a raw material for the synthesis of complex chemical compounds. Its unique combination of difluoro and propyne functional groups allows for versatile reactions, making it a valuable component in the creation of advanced molecules for various applications.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 1,4-difluoro-2-(prop-2-ynyloxy)benzene is utilized as a building block for the development of new drugs. Its structural features enable the formation of novel molecular entities with potential therapeutic properties, contributing to the advancement of medicinal chemistry.
Used in Material Science:
1,4-Difluoro-2-(prop-2-ynyloxy)benzene is employed in material science as a component in the design and synthesis of new materials with specific properties. Its incorporation into polymers and other materials can lead to the development of materials with tailored characteristics, such as improved thermal stability, chemical resistance, or electronic properties.
Used in Research and Development:
In academic and industrial research settings, 1,4-difluoro-2-(prop-2-ynyloxy)benzene is used as a model compound for studying the effects of difluoro and propyne functional groups on chemical reactivity and stability. This understanding can inform the design of new synthetic pathways and the development of innovative materials and compounds.

Upstream product

• 2713-31-7 2,5-difluorophenol 
• 106-96-7 propargyl bromide 

Relevant academic research and scientific papers

A Unique Synthesis of 5,8-Difluoro-2 H -chromene Using Silicone Oil as a Solvent

A significantly improved synthesis of 5,8-difluoro-2H-chromene 1 using silicone oil as the reaction solvent is described. The new method eliminated the tedious workup and large quantity of waste produced via conventional methods. To our best knowledge, th

Synthesis of sorafenib analogues incorporating a 1,2,3-triazole ring and cytotoxicity towards hepatocellular carcinoma cell lines

A series of 1,2,3-triazole-containing Sorafenib analogues, in which the aryl urea moiety of Sorafenib (1) was replaced with a 1,2,3-triazole ring linking a substituted phenoxy fragment, were prepared successfully via Huisgen 1,3-dipolar cycloaddition and

Enantio- and Diastereoselective, Complete Hydrogenation of Benzofurans by Cascade Catalysis

We report an enantio- and diastereoselective, complete hydrogenation of multiply substituted benzofurans in a one-pot cascade catalysis. The developed protocol facilitates the controlled installation of up to six new defined stereocenters and produces architecturally complex octahydrobenzofurans, prevalent in many bioactive molecules. A unique match of a chiral homogeneous ruthenium-N-heterocyclic carbene complex and an in situ activated rhodium catalyst from a complex precursor act in sequence to enable the presented process.

BTK Inhibitors and uses thereof

The invention discloses a bruton's tyrosine kinase (BTK) inhibitor and use thereof. Specifically, the invention provides heteroaromatic compounds or stereoisomers, geometrical isomers, tautomers, racemates, nitrogen oxides, hydrates, solvates, metabolites and pharmaceutically acceptable salts or prodrugs thereof, and pharmaceutical compositions containing the heteroaromatic compounds; the invention also discloses use of the heteroaromatic compounds or the pharmaceutical compositions containing the heteroaromatic compounds in preparation of medicines; the medicines can be used for treating autoimmune diseases, inflammatory diseases or proliferative diseases.