457630-84-1

Upstream product

• 457630-92-1 (E)-(2R,3R,6S)-3-(tert-Butyl-dimethyl-silanyloxy)-2,6-dimethyl-non-4-enoic acid (1R,2S)-2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl ester 
• 457630-83-0 (E)-(2R,3R,6S)-3-Hydroxy-2,6-dimethyl-non-4-enoic acid (1R,2S)-2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl ester 
• 98-59-9 p-toluenesulfonyl chloride 
• 457630-93-2 (E)-(2S,3R,6S)-3-(tert-Butyl-dimethyl-silanyloxy)-2,6-dimethyl-non-4-en-1-ol 

Relevant academic research and scientific papers

Total synthesis of proposed amphidinolide a via a highly selective ring-closing metathesis

(figure presented) key retrosynthetic disconnections a: ring closing metathesis b: indium mediated allylation c: stereoselective anti-aldol d: Mitsunobo esterification e: Stille reaction f-g: chelation controlled add'n A highly convergent synthesis of the