457634-22-9

Upstream product

• 876-02-8 4-hydroxy-3-methylphenyl methyl ketone 
• 100306-34-1 3-chloro-1-phenylpropanol 
• 727418-37-3 1-[4-((R)-3-Chloro-1-phenyl-propoxy)-3-methyl-phenyl]-ethanone 

Relevant academic research and scientific papers

Synthesis and biological evaluation of the major metabolite of atomoxetine: Elucidation of a partial κ-opioid agonist effect

The major human metabolite of atomoxetine (4-hydroxyatomoxetine) was tested against a panel of receptors and enzymes, and was found to interact with the μ, δ, and κ-opioid receptors based upon studies involving both binding and functional assays. 4-Hydroxyatomoxetine was determined to be a partial agonist of the κ-opioid receptor.