457654-55-6 Usage
General Description
D,L-3-chlorophenylalanine ethyl ester hydrochloride is a chemical compound that belongs to the class of phenylalanine derivatives. It is an ethyl ester derivative of D,L-3-chlorophenylalanine and is commonly used in research and drug development. It has been studied for its potential therapeutic effects in treating various conditions, including depression, pain, and certain types of cancer. Its hydrochloride salt form enhances its stability and solubility in aqueous solutions, making it more suitable for use in research and pharmaceutical applications. The compound's precise mechanisms of action and potential side effects and toxicity have been the subject of ongoing investigation.
Check Digit Verification of cas no
The CAS Registry Mumber 457654-55-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,5,7,6,5 and 4 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 457654-55:
(8*4)+(7*5)+(6*7)+(5*6)+(4*5)+(3*4)+(2*5)+(1*5)=186
186 % 10 = 6
So 457654-55-6 is a valid CAS Registry Number.
457654-55-6Relevant articles and documents
Anthranilic acid based CCK1 receptor antagonists: Preliminary investigation on their second "touch point"
Varnavas, Antonio,Lassiani, Lucia,Valenta, Valentina,Mennuni, Laura,Makovec, Francesco,Hadjipavlou-Litina, Dimitra
, p. 563 - 581 (2007/10/03)
In this phase of structure-affinity relationship study of VL-0395, a new anthranilic acid based CCK1 selective antagonist, we propose a series of unnatural aminoacidic derivatives. The result of this work is the identification of a new CCK ligand, which possesses an affinity (IC50 = 35 nm) one order of magnitude greater than the lead and, as a general rule, it points out how the hypothesized receptorial pocket which accommodates the Phe residue allows much more structural modification than that interacting with the N-terminal group. Hence, the modification of the C-terminal pharmacophoric group of our lead VL-0395 can not only enhance the affinity of anthranilic acid derivatives but can modulate the selectivity for one CCK receptor subtype or afford mixed antagonists.
