457657-65-7Relevant academic research and scientific papers
Preparation of cyclic and bicyclic β-amino acids derivatives from methyl 6-ethoxy-5,6-dihydro-4h-1,2-oxazine-4-carboxylate
Tishkov, Alexander A.,Reissig, Hans-Ulrich,Ioffe, Sema L.
, p. 863 - 866 (2002)
The readily available methyl 6-ethoxy-5,6-dihydro-4H-1,2-oxazine-4-carboxylate (1) was alkylated at C-4 and acylated at the nitrogen atom. 1,2-Oxazine 1 and the resulting new substituted 1,2-oxazines 2 and 3 were suitable precursors for the preparation of derivatives of β-proline, nipecotic acid, as well as indolizine-6- and quinolizine-3-carboxylic acids.
