457951-87-0Relevant academic research and scientific papers
Transformation of substituted 5-amino-1,3-oxazole-4-carbonitriles into new 3,4,5-triaminopyrazole derivatives
Kozachenko,Shablykin,Vasilenko,Brovarets
experimental part, p. 127 - 132 (2010/05/01)
Reactions of accessible 5-alkylamino- and 5-arylamino-1,3-oxazole-4- carbonitriles with hydrazine hydrate on heating involved a complex transformation sequence resulting in the formation of 3,4,5-triaminopyrazole derivatives. The structure of the products was confirmed by their cyclocondensation with acetylacetone, leading to 2-alkyl(aryl)amino-3-acylamino- 5,7-dimethylpyrazolo[1,5-a]pyrimidines which were identified by NMR spectroscopy using COSY, NOESY, HMQC, and HMBC techniques.
