458-51-5

Basic information

• Product Name: 3-FLUORO-4-IODOANISOLE
• Synonyms: 3-FLUORO-4-IODOANISOLE;2-fluoro-1-iodo-4-methoxybenzene
• CAS NO: 458-51-5
• Molecular Formula: C₇H₆FIO
• Molecular Weight: 252.02
• Mol File: 458-51-5.mol

Chemical Properties

• Boiling Point: 223.1°C at 760 mmHg
• Flash Point: 88.7°C
• Appearance: /
• Density: 1.803g/cm³
• Vapor Pressure: 0.146mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: 3-FLUORO-4-IODOANISOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-4-IODOANISOLE(458-51-5)
• EPA Substance Registry System: 3-FLUORO-4-IODOANISOLE(458-51-5)

Safety Data

• Hazardous Substances Data: 458-51-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
3-Fluoro-4-iodoanisole is used as a key intermediate in the synthesis of pharmaceuticals for its ability to incorporate fluorine and iodine atoms into complex molecular structures, enhancing the properties and effectiveness of the resulting drugs.
Used in Organic Chemistry:
As a versatile building block, 3-fluoro-4-iodoanisole is used in organic chemistry to construct more intricate organic compounds, leveraging its capacity to introduce halogens into molecular frameworks.
Used in Agrochemical Development:
3-Fluoro-4-iodoanisole is utilized in the development of agrochemicals, where its unique reactivity and structural properties contribute to the creation of effective products for agricultural applications.
Used in Dye and Fine Chemicals Production:
3-FLUORO-4-IODOANISOLE is also used in the production of dyes and other fine chemicals, where its specific chemical attributes are harnessed to produce high-quality specialty products.
In all applications, it is essential to follow proper safety measures and handling techniques to ensure the safe use of 3-fluoro-4-iodoanisole in laboratory and industrial settings.

InChI:InChI=1/C7H6FIO/c1-10-5-2-3-7(9)6(8)4-5/h2-4H,1H3

Upstream product

• 458-52-6 2-fluoro-4-(methoxy)aniline 
• 446-38-8 2-fluoro-4-methoxy-1-nitro-benzene 
• 2265-93-2 2,4-difluoro-1-iodobenzene 
• 865-33-8 potassium methanolate 

Downstream Products

• 1610039-11-6 ((2R,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methanol 
• 1610036-14-0 methyl 2-((2S,3S,4R)-4-acetoxy-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-3-methylpyrrolidin2-yl)acetate 
• 1610039-12-7 methyl 2-((2S,3S,4R)-1-(2-fluoro-4-hydroxyphenyl)-4-hydroxy-3-methylpyrrolidin-2-yl)acetate 
• 1610036-13-9 methyl 2-((2S,3S,4R)-4-acetoxy-1-(2-fluoro-4-hydroxyphenyl)-3-methylpyrrolidin-2-yl)acetate 
• 1610036-12-8 methyl 2-((2S,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetate 
• 1610036-11-7 2-((2S,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3methylpyrrolidin-2-yl)acetonitrile 
• 1610036-10-6 2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-hydroxy-3-methylpyrrolidin-2-yl)acetic acid 

Relevant articles and documents

PIPERIDINES OR PIPERIDONES SUBSTITUTED WITH UREA AND PHENYL

The present invention relates to a compound according to general formula (I) which acts as a modulator of FPR2 and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by FPR2.

PYRROLIDINE GPR40 MODULATORS

The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.

Regioselective SNAr reactions of substituted difluorobenzene derivatives: practical synthesis of fluoroaryl ethers and substituted resorcinols

In this Letter, we describe a practical and highly selective method for the preparation of fluoroaryl ethers and differentially substituted resorcinol derivatives. This synthetic strategy relies on a selective SNAr of substituted difluorobenzen