458-51-5

Basic information

• Product Name: 3-FLUORO-4-IODOANISOLE
• Synonyms: 3-FLUORO-4-IODOANISOLE;2-fluoro-1-iodo-4-methoxybenzene
• CAS NO: 458-51-5
• Molecular Formula: C₇H₆FIO
• Molecular Weight: 252.02
• Mol File: 458-51-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 223.1°C at 760 mmHg
• Flash Point: 88.7°C
• Appearance: /
• Density: 1.803g/cm³
• Vapor Pressure: 0.146mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: 3-FLUORO-4-IODOANISOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-4-IODOANISOLE(458-51-5)
• EPA Substance Registry System: 3-FLUORO-4-IODOANISOLE(458-51-5)

Safety Data

• Hazardous Substances Data: 458-51-5(Hazardous Substances Data)

Usage

General Description

3-Fluoro-4-iodoanisole is a chemical compound with the molecular formula C7H6FOI. It is a clear, colorless liquid at room temperature and is commonly used in the synthesis of various pharmaceuticals and organic compounds. 3-FLUORO-4-IODOANISOLE is a versatile building block in organic chemistry, as it can be used to introduce fluorine and iodine atoms into more complex molecules. 3-Fluoro-4-iodoanisole is also utilized in the development of agrochemicals, dyes, and other fine chemicals due to its unique reactivity and structural properties. It is important to handle this compound with caution, as it may be harmful if ingested, inhaled, or absorbed through the skin. Proper safety measures and handling techniques should be followed when working with 3-fluoro-4-iodoanisole to ensure safe use in laboratory and industrial settings.

InChI:InChI=1/C7H6FIO/c1-10-5-2-3-7(9)6(8)4-5/h2-4H,1H3

Upstream product

• 2265-93-2 2,4-difluoro-1-iodobenzene 
• 865-33-8 potassium methanolate 
• 446-38-8 2-fluoro-4-methoxy-1-nitro-benzene 
• 458-52-6 2-fluoro-4-(methoxy)aniline 

Downstream Products

• 1610036-10-6 2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-hydroxy-3-methylpyrrolidin-2-yl)acetic acid 
• 1610036-11-7 2-((2S,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3methylpyrrolidin-2-yl)acetonitrile 
• 1610036-12-8 methyl 2-((2S,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetate 
• 1610036-13-9 methyl 2-((2S,3S,4R)-4-acetoxy-1-(2-fluoro-4-hydroxyphenyl)-3-methylpyrrolidin-2-yl)acetate 
• 1610039-12-7 methyl 2-((2S,3S,4R)-1-(2-fluoro-4-hydroxyphenyl)-4-hydroxy-3-methylpyrrolidin-2-yl)acetate 
• 1610036-14-0 methyl 2-((2S,3S,4R)-4-acetoxy-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-3-methylpyrrolidin2-yl)acetate 
• 1610039-11-6 ((2R,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methanol 

Relevant articles and documents

PIPERIDINES OR PIPERIDONES SUBSTITUTED WITH UREA AND PHENYL

The present invention relates to a compound according to general formula (I) which acts as a modulator of FPR2 and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by FPR2.

Regioselective SNAr reactions of substituted difluorobenzene derivatives: practical synthesis of fluoroaryl ethers and substituted resorcinols

In this Letter, we describe a practical and highly selective method for the preparation of fluoroaryl ethers and differentially substituted resorcinol derivatives. This synthetic strategy relies on a selective SNAr of substituted difluorobenzen