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N-[(4-fluorophenyl)methyl]thiazole 2-amine is a chemical compound with the molecular formula C11H10FN3S. It is a derivative of thiazole, a heterocyclic compound consisting of a five-membered ring with one sulfur atom and two nitrogen atoms. The compound features a 4-fluorophenylmethyl group attached to the nitrogen atom at position 2 of the thiazole ring, which contributes to its unique chemical properties. N-[(4-fluorophenyl)methyl]thiazole 2-amine is often used in the synthesis of various pharmaceuticals and agrochemicals due to its potential biological activity and ability to form stable complexes with other molecules. Its specific applications may vary depending on the target molecule or therapeutic area, but it is generally recognized for its potential role in drug design and development.

458-72-0

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458-72-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 458-72-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,5 and 8 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 458-72:
(5*4)+(4*5)+(3*8)+(2*7)+(1*2)=80
80 % 10 = 0
So 458-72-0 is a valid CAS Registry Number.

458-72-0Relevant academic research and scientific papers

Design, synthesis and biological evaluation of new 1,3-thiazole derivatives as potential anti-inflammatory agents

Modri?, Marina,Bo?i?evi?, Marin,Faraho, Ivan,Bosnar, Martina,?kori?, Irena

, (2021)

Thiazoles are widely recognized as nuclei of great value for obtaining molecules with various biological activities, including analgesic, anti-inflammatory, anti-HIV, antidiabetic, antitumor and antimicrobial. A library of 26 thiazole derivatives as fragments were designed, synthesized and evaluated for their anti-inflammatory activities. Some screened compounds showed promising results and were found to be potent in the series by inhibiting LPS-induced TNFα and IL-8 release with IC50 values in μM range without cytotoxic activity.

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