458-74-2

Upstream product

• 624-67-9 Propargylic aldehyde 
• 405-73-2 (4-fluoro-benzyl)-guanidine; hydrochloride 
• 140-75-0 para-fluorobenzylamine 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 365-77-5 N-(4-fluoro-benzyl)-N',N'-dimethyl-N-pyrimidin-2-yl-ethylenediamine 
• 1358694-03-7 1-(4-fluorobenzyl)-4-((3',5'-dimethoxybiphenyl-3-yl)methyl)-1H-imidazol-2-amine 
• 1358694-05-9 1-(4-fluorobenzyl)-4-((3',5'-dimethoxybiphenyl-4-yl)methyl)-1H-imidazol-2-amine 
• 1358693-96-5 4-benzyl-1-(4-fluorobenzyl)-1H-imidazol-2-amine 

Relevant academic research and scientific papers

Research on antibacterial and antifungal agents. XI. Synthesis and antimicrobial activity of N-heteroaryl benzylamines and their schiff bases

The synthesis and antimicrobial activity of new N-heteroaryl benzylamines and their Schiff bases are reported. Antifungal data were compared with those obtained with miconazole, ketoconazole, enilconazole and imazalil sulfate, which showed that some of the tested compounds possessed moderate activity against strains of Candida albicans, Candida Sp and good activity against isolates of plant pathogenic fungi. In contrast the synthesized compounds showed poor antibacterial activity, except for 3j which exhibited abetter activity than nalidixic acid used as positive control. The results obtained are discussed on the basis of structure-activity relationships.