4582-65-4

Upstream product

• 3199-47-1 (5-bromo-[2]furyl)-propiolic acid 
• 38898-09-8 ethyl 3-(furan-2-yl)prop-2-ynoate 
• 584-12-3 2-bromofuran 
• 471-25-0 Propiolic acid 

Downstream Products

• 131292-13-2 ethyl 5-(2-furyl)-3-oxo-2-triphenylphosphoranylidenepent-4-ynoate 
• 1217554-43-2 1-(4-methoxyphenyl)-4-(2-furfuryl)buta-1,3-diyne 
• 1334220-39-1 1-nitro-4-(2'-furfurylethynyl)benzene 
• 1224168-97-1 2-(2-(4-methoxyphenyl)ethynyl)furan 

Relevant academic research and scientific papers

Enantioselective hydroesterificative cyclization of 1,6-enynes to chiral γ-lactams bearing a quaternary carbon stereocenter

A palladium-catalyzed asymmetric hydroesterification-cyclization of 1,6-enynes with CO and alcohol was developed to efficiently prepare a variety of enantioenriched γ-lactams bearing a chiral quaternary carbon center and a carboxylic ester group. The approach featured good to high chemo-, region-, and enantioselectivities, high atom economy, and mild reaction conditions as well as broad substrate scope. The correlation between the multiple selectivities of such process and the N-substitutes of the amide linker in the 1,6-enyne substrate has been depicted by the crystallographic evidence and control experiments.

Flash Vacuum Pyrolysis of Stabilised Phosphorous Ylides. Part 4. Stepwise Construction of Terminal 1,3-Diynes, Conjugated Diacetylenic Esters and a Triacetylenic Ester

Thirteen examples of stabilised alkynol ylides 6 have been prepared and are found, upon flash vacuum pyrolysis (FVP) at 500 deg C, to undergo extrusion of Ph3PO to give the diacetylenic esters 7 in moderate yield.At 750 deg C the same ylides afforded terminal 1,3-diynes 8 although often in poor yield.For R = 2-MeSC6H4 both 7 and 8 undergo secondary loss of Me* and cyclisation to give 2-alkynylbenzothiophene derivatives 9 and 10 in low yield.The first example of an alkadiynol ylide 11 has been prepared and is converted by FVP at 500 deg C into the triacetylenic ester 12.