45848-29-1

Basic information

• Product Name: 2-chloro-6-methyl-N,N-dimethylaniline
• Synonyms: 2-chloro-6-methyl-N,N-dimethylaniline
• CAS NO: 45848-29-1
• Molecular Weight: 169.654
• Mol File: 45848-29-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-chloro-6-methyl-N,N-dimethylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-6-methyl-N,N-dimethylaniline(45848-29-1)
• EPA Substance Registry System: 2-chloro-6-methyl-N,N-dimethylaniline(45848-29-1)

Safety Data

• Hazardous Substances Data: 45848-29-1(Hazardous Substances Data)

Upstream product

• 6852-47-7 N,N-dimethyl-N-(2'-methylphenyl)amine N-oxide 
• 609-72-3 N,N-dimethyl-o-toluidine 
• 87-63-8 2-chloro-6-methylaniline 
• 74-88-4 methyl iodide 

Relevant articles and documents

Synthesis of Halogenated Anilines by Treatment of N, N-Dialkylaniline N-Oxides with Thionyl Halides

The special reactivity of N,N-dialkylaniline N-oxides allows practical and convenient access to electron-rich aryl halides. A complementary pair of reaction protocols allow for the selective para-bromination or ortho-chlorination of N,N-dialkylanilines in up to 69% isolated yield. The generation of a diverse array of halogenated anilines is made possible by a temporary oxidation level increase of N,N-dialkylanilines to the corresponding N,N-dialkylaniline N-oxides and the excision of the resultant weak N-O bond via treatment with thionyl bromide or thionyl chloride at low temperature.