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2-[(1-benzyl-5-chloro-1H-indazol-3-yl)oxy]-N,N-dimethylethanamine hydrochloride (1:1) is a hydrochloride salt form of a compound with a molecular formula C20H23ClN4O. It is a potential antineoplastic agent that primarily targets the enzyme EZH2 (enhancer of zeste homolog 2), a histone methyltransferase. By inhibiting EZH2 activity, 2-[(1-benzyl-5-chloro-1H-indazol-3-yl)oxy]-N,N-dimethylethanamine hydrochloride (1:1) can reduce the trimethylation of histone H3 at lysine 27 (H3K27me3), leading to the upregulation of target genes and the inhibition of cancer cell proliferation. It is currently under investigation for its potential use in treating various types of cancer, including lymphoma and solid tumors.

4585-78-8

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4585-78-8 Usage

Uses

Used in Oncology:
2-[(1-benzyl-5-chloro-1H-indazol-3-yl)oxy]-N,N-dimethylethanamine hydrochloride (1:1) is used as an antineoplastic agent for its ability to inhibit the activity of EZH2, a histone methyltransferase enzyme. This inhibition leads to a reduction in the trimethylation of histone H3 at lysine 27 (H3K27me3), which in turn results in the upregulation of target genes and the suppression of cancer cell proliferation. It is being studied for its potential application in the treatment of various types of cancer, such as lymphoma and solid tumors.
Used in Drug Development for Cancer Therapy:

Check Digit Verification of cas no

The CAS Registry Mumber 4585-78-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,5,8 and 5 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 4585-78:
(6*4)+(5*5)+(4*8)+(3*5)+(2*7)+(1*8)=118
118 % 10 = 8
So 4585-78-8 is a valid CAS Registry Number.

4585-78-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(1-benzyl-5-chloroindazol-3-yl)oxy-N,N-dimethylethanamine,hydrochloride

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

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More Details:4585-78-8 SDS

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