458528-08-0Relevant academic research and scientific papers
The versatile conversion of lactams to the α-alkylated azacycles via cyclic N,O-acetal TMS ether
Suh, Young-Ger,Kim, Seok-Ho,Jung, Jae-Kyung,Shin, Dong-Yun
, p. 3165 - 3167 (2002)
The efficient preparation of the cyclic N,O-acetals from lactams by DIBAL reduction followed by direct trapping of the resulting N,O-hemiacetals using TMSOTf/pyridine system is described. In addition, the facile nucleophilic addition of various carbon nucleophiles at the carbonyl carbons of the lactams through the corresponding N,O-acetals is also reported.
