458531-56-1

Basic information

• Product Name: Carbamic acid, [(1S)-2-hydroxy-1-methyl-3-butenyl]-, 1,1-dimethylethyl ester
• Synonyms: Carbamic acid, [(1S)-2-hydroxy-1-methyl-3-butenyl]-, 1,1-dimethylethyl ester
• CAS NO: 458531-56-1
• Molecular Formula: C₁₀H₁₉NO₃
• Molecular Weight: 201.26276
• Product Categories: N-BOC
• Mol File: 458531-56-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, [(1S)-2-hydroxy-1-methyl-3-butenyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-2-hydroxy-1-methyl-3-butenyl]-, 1,1-dimethylethyl ester(458531-56-1)
• EPA Substance Registry System: Carbamic acid, [(1S)-2-hydroxy-1-methyl-3-butenyl]-, 1,1-dimethylethyl ester(458531-56-1)

Safety Data

• Hazardous Substances Data: 458531-56-1(Hazardous Substances Data)

Upstream product

• 28875-17-4 (S)-N-(tert-butoxycarbonyl)alanine methyl ester 
• 3536-96-7 vinylmagnesium chloride 
• 1826-67-1 vinyl magnesium bromide 
• 79069-50-4 Boc-Ala-H 
• 79069-13-9 (S)-2-t-butoxycarbonylaminopropan-1-ol 

Downstream Products

• 1335287-06-3 (S)-2-[(1S,2R)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyloxycarbonyl]-1-methylethyl (2E,4R,5S)-5-{N-acryloyl-(E)-[2-methyl-3-(2-methyl-4-thiazolyl)allyl]amino}-4-(2-methoxyethoxy)methoxy-2-hexenoate 
• 1335287-01-8 (S)-2-[(1S,2R)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyloxycarbonyl]-1-methylethyl (2E,4R,5S)-5-(N-acryloyl-N-(4-methyl-2-thiazolyl)methylamino)-4-(2-methoxyethoxy)methoxy-2-hexenoate 
• 1335286-96-8 (S)-2-[(1S,2R)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyloxycarbonyl]-1-methylethyl (2E,4R,5S)-5-(N-acryloyl-N-(2-methyl-4-thiazolyl)methylamino)-4-(2-methoxyethoxy)methoxy-2-hexenoate 
• 1335286-91-3 (S)-2-[(1S,2R)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyloxycarbonyl]-1-methylethyl (2E,4R,5S)-5-(N-acryloyl-N-phenethylamino)-4-(2-methoxyethoxy)methoxy-2-hexenoate 
• 1335286-86-6 (S)-2-[(1S,2R)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyloxycarbonyl]-1-methylethyl (2E,4R,5S)-5-(N-acryloyl-N-benzylamino)-4-(2-methoxyethoxy)methoxy-2-hexenoate 
• 1335286-64-0 (1S,2R)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyl (2E,4R,5S)-5-[(S)-3-acryloyloxybutyryl]amino-4-(2-methoxyethoxy)methoxy-2-hexenoate 
• 1335286-63-9 (1S,2R)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyl (2E,4R,5S)-5-[(S)-3-hydoxybutyryl]amino-4-(2-methoxyethoxy)methoxy-2-hexenoate 
• 1335287-18-7 C₂₃H₂₅NO₇ 
• 1335287-17-6 C₂₃H₂₉NO₇ 
• 1335286-74-2 (3S,6E,8R,9S,12E,14R,15S)-16-benzyl-14-hydroxy-8-(2-methoxyethoxy)methoxy-3,9,15-trimethyl-16-aza-4,10-dioxa-6,12-cyclohexadecadiene-1,5,11-trione 
• 1335286-73-1 (S)-3-{N-benzyl-N-[(1R,2S)-2-hydroxy-1-methylbutenyl]amino}-1-methyl-3-oxo-propyl (2E,4R,5S)-5-acryloyloxy-4-(2-methoxyethoxy)methoxy-2-hexenoate 
• 1335286-72-0 (S)-3-{N-benzyl-N-[(1R,2S)-2-tert-butyldiphenylsilyloxy-1-methylbutenyl]amino}-1-methyl-3-oxo-propyl (2E,4R,5S)-5-acryloyloxy-4-(2-methoxyethoxy)methoxy-2-hexenoate 
• 1335286-71-9 (S)-3-{N-benzyl-N-[(1R,2S)-2-tert-butyldiphenylsilyloxy-1-methylbutenyl]amino}-1-methyl-3-oxo-propyl (2E,4R,5S)-5-hydroxy-4-(2-methoxyethoxy)methoxy-2-hexenoate 
• 1335286-70-8 (S)-3-{N-benzyl-N-[(1R,2S)-2-tert-butyldiphenylsilyloxy-1-methylbutenyl]amino}-1-methyl-3-oxo-propyl (2E,4R,5S)-5-tert-butyldiphenylsilyloxy-4-(2-methoxyethoxy)methoxy-2-hexenoate 

Relevant articles and documents

Concise total synthesis of (+)-carpamic acid

We report herein an efficient enantioselective synthesis of (+)-carpamic acid, with nine steps as the longest linear sequence, the key strategy being based on a novel sequence of a cross-metathesis (CM) reaction and a subsequent cyclizing reductive amination to form the piperidine ring.

Palladium-catalyzed formation and stereoselective isomerization of 5- vinyloxazolines. Application to the formal synthesis of (S,S)-4-amino-3- hydroxy-5-phenylpentanoic acid

Vinyloxazolidinones have been found to undergo Pd(0)-catalyzed ionization followed by loss of carbon dioxide and subsequent cyclization to form vinyloxazolines. The reaction occurred under mild conditions, and enhancement of diastereomeric ratios with chiral substrates was obtained. 4- Benzyl-5-vinyloxazoline prepared by this method has been utilized in the stereoselective synthesis of (S,S)-4-amino-3-hydroxy-5-phenylpentanoic acid (AHPPA).