458531-59-4Relevant articles and documents
Novel Bicyclic Pyridinones
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Page/Page column, (2014/04/03)
Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
Asymmetric synthesis of ES-285, an anticancer agent isolated from marine sources
Allepuz, Ana C.,Badorrey, Ramon,Diaz-de-Viliegas, Maria D.,Galvez, Jose A.
experimental part, p. 6172 - 6178 (2010/03/26)
The asymmetric synthesis of (2S,3R)-2-amino-3-octane-decanol hydrochloride (ES-285-HC1) was achieved in eight steps in ca. 38% overall yield from the N-benzylimine-derived from. (R)-2,3-O-isopropylidene glyceraldehyde, which is easily available on gram sc
Synthesis and γ-secretase activity of APP substrate-based hydroxyethylene dipeptide isosteres
Nadin, Alan,Owens, Andrew P.,Castro, José L.,Harrison, Timothy,Shearman, Mark S.
, p. 37 - 41 (2007/10/03)
Two new APP substrate-based hydroxyethylene isosteres (AT and VI) were prepared and their dipeptide conjugates shown not to inhibit the γ-secretase-mediated formation of either Aβ1-40 or Aβ1-42. The FG isostere and a des-hydroxy hydroxyethylene isostere a