458533-81-8

Upstream product

• 115846-96-3 (1E,4E)-1-phenyl-5-(p-tolyl)penta-1,4-dien-3-one 
• 138723-90-7 2,5-dihydro-2,2-dimethoxy-5,5-dimethyl-1,3,4-oxadiazole 
• 762-42-5 dimethyl acetylenedicarboxylate 

Relevant academic research and scientific papers

A novel approach to the synthesis of bicyclic lactones via an interrupted nazarov reaction of gem-divinyl dihydrofurans

(figure presented) A facile Lewis acid induced interrupted Nazarov reaction of gem-divinyl dihydrofurans to bicyclic lactones is described.

Novel dipolar cycloaddition reactions of zwitterionic species generated from dimethoxycarbene and dimethyl acetylenedicarboxylate with carbonyl compounds: Facile synthesis of dihydrofuran derivatives

The reaction of 1:1 zwitterionic species, generated in situ by the addition of dimethoxycarbene to dimethyl acetylenedicarboxylate, towards carbonyl compounds is described. The reactions presented offer a one-pot synthesis of dihydrofuran and spiro dihydrofuran derivatives in high yields.