458550-87-3Relevant academic research and scientific papers
Efficient synthesis of novel macrocyclic tetraamide compounds: A unique reaction process involving both self-assembling and folding of intermediates
Numata, Munenori,Hiratani, Kazuhisa,Nagawa, Yoshinobu,Houjou, Hirohiko,Masubuchi, Sayuri,Akabori, Sadatoshi
, p. 503 - 507 (2002)
A macrocycle having two isobutenyl and four amide moieties was successfully formed via two kinds of acyclic intermediates. These key intermediates possess the ability to self-organize due to intra- or intermolecular hydrogen-bonding interactions. In both intermediates, preorganized structures were favorably subject to nucleophilic attack at the carbonyl group by a terminal amino group, and preorganization made it possible to form the macro-cycle under mild conditions.
