4589-66-6

Usage

Uses

Used in Pharmaceutical Industry:
1H-Benzimidazole-5-methanol,1,2-dimethyl-(9CI) is used as an intermediate in the synthesis of various drugs for its potential applications in the development of new medicines.
Used in Organic Compounds Synthesis:
1H-Benzimidazole-5-methanol,1,2-dimethyl-(9CI) is used as a key component in the synthesis of other organic compounds due to its unique chemical properties.
Used in Anti-Inflammatory Applications:
1H-Benzimidazole-5-methanol,1,2-dimethyl-(9CI) is used as an anti-inflammatory agent for its ability to reduce inflammation and alleviate pain.
Used in Anti-Cancer Applications:
1H-Benzimidazole-5-methanol,1,2-dimethyl-(9CI) is used as an anti-cancer agent for its potential to inhibit the growth and progression of cancer cells.
Used in Anti-Microbial Applications:
1H-Benzimidazole-5-methanol,1,2-dimethyl-(9CI) is used as an anti-microbial agent for its ability to inhibit the growth of microorganisms and prevent infections.

Upstream product

• 256936-11-5 1,2-dimethyl-1H-benzo[d]imidazole-5-carboxylic acid methyl ester 

Downstream Products

• 4597-21-1 1,2-dimethyl-1H-benzo[d]imidazole-5-carbaldehyde 
• 256936-11-5 1,2-dimethyl-1H-benzo[d]imidazole-5-carboxylic acid methyl ester 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUND AND p27Kip1 DEGRADATION INHIBITOR

A novel heterocyclic compound or a salt thereof useful for selectively inhibiting the degradation of p27Kip1 is provided. The compound or the salt thereof is represented by the following formula (1): wherein A represents an alkyl group, a cycloalkyl group, an aryl group or a heterocyclic group, the group A may have a substituent; the ring B represents a 5- to 8-membered monocyclic heterocyclic ring or a condensed ring containing the monocyclic heterocyclic ring, the ring B may have a substituent; the ring C represents an aromatic ring, the ring C may have a substituent; L represents a linker comprising a main chain having 3 to 5 atoms selected from the group consisting of a carbon atom, a nitrogen atom, an oxygen atom and a sulfur atom, wherein at least one atom in the main chain is a hetero atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, the linker L may have a substituent; and n is 0 or 1.

N-((6-AMINO-PYRIDIN-3-YL)METHYL)-HETEROARYL-CARBOXAMIDES

The invention relates to compound of the formula I in which the substituents are as defined in the specification; in free form or in salt form; to its preparation, to its use as medicament and to medicaments comprising it.

Total synthesis of hypermodified epothilone analogs with potent in vitro antitumor activity

The convergent total synthesis of hypermodified epothilone analogs 1 and 2 has been achieved with the stereoselective cyclopropanation of allylic alcohol 17 and ring-closing olefin metathesis with diene 22 as the key steps. In spite of significant structural differences between these analogs and the natural epothilone scaffold, 1 and 2 are potent inducers of tubulin polymerization and inhibit the growth of human cancer cells in vitro with sub-nM IC50 values.