459144-94-6

Upstream product

• 459144-92-4 1-{(2R,3R)-3-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-propyl]-oxiranyl}-3-trimethylsilanyl-prop-2-yn-1-ol 
• 459144-93-5 1-{(2R,3R)-3-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-propyl]-oxiranyl}-prop-2-yn-1-ol 
• 824-94-2 p-methoxybenzyl chloride 
• 459144-91-3 tert-Butyl-((S)-2-{(2R,3S)-3-[1-(4-methoxy-benzyloxy)-prop-2-ynyl]-oxiranyl}-1-methyl-ethoxy)-dimethyl-silane 

Downstream Products

• 459145-00-7 6-(tert-Butyl-dimethyl-silanyloxy)-8-hydroxy-3-[(E)-4-[(2S,3R)-3-((S)-2-hydroxy-propyl)-oxiranyl]-4-(4-methoxy-benzyloxy)-but-2-enyl]-isochromen-1-one 
• 459144-99-1 6,8-Bis-(tert-butyl-dimethyl-silanyloxy)-3-[(E)-4-[(2S,3R)-3-((S)-2-hydroxy-propyl)-oxiranyl]-4-(4-methoxy-benzyloxy)-but-2-enyl]-isochromen-1-one 

Relevant academic research and scientific papers

Improvements of the total synthesis of monocillin I and radicicol via Miyaura-Suzuki couplings

The palladium-catalyzed coupling of the vinyldisiamylborane, formed in situ, affords the isocoumarins which can be used further for the synthesis of radicicol and related macrolides, in 72% global overall yield from the alkyne. Advantages over related vinylboronates or vinyltin couplings are discussed in the case of the present examples.