459164-66-0Relevant academic research and scientific papers
Multisubstituted C2-symmetric ansa -metallocenes bearing nitrogen heterocycles: Influence of substituents on catalytic properties in propylene polymerization at higher temperatures
Canich, Jo Ann M.,Goryunov, Georgy P.,Izmer, Vyatcheslav V.,Kononovich, Dmitry S.,Kulyabin, Pavel S.,Sharikov, Mikhail I.,Uborsky, Dmitry V.,Voskoboynikov, Alexander Z.
supporting information, p. 6170 - 6180 (2021/05/19)
In this work we systematically studied the effects of modifications of substituents on the performance of the isospecific zirconocene-based catalyst family, Me2Si(2-Alk-4-(N-carbazolyl)Ind)ZrX2 (X = Cl, Me), wherein the progenitor was shown to be particul
Rational design of potent and selective NH-linked aryl/heteroaryl cathepsin K inhibitors
Robichaud, Joel,Bayly, Christopher,Oballa, Renata,Prasit, Peppi,Mellon, Christophe,Falgueyret, Jean-Pierre,David Percival,Wesolowski, Gregg,Rodan, Sevgi B.
, p. 4291 - 4295 (2007/10/03)
Prior reports from our laboratories have identified the nonpeptidic inhibitor 2 as a potent and selective Cathepsin K (Cat K) inhibitor. Modelling studies suggested that the introduction of a NH linker between the P3 aryl and P2 leucinamide moieties would allow the formation of a H-bond with the Gly66 residue of Cat K, hopefully increasing potency. Aniline 4 was thus synthesized and showed improved potency over its predecessor 2. Further modelling concluded that a 2-substituted five membered ring could more adequately place the P3 moiety of 4 into the S3 pocket of Cat K. The synthesis of the 2-substituted thiophene 5 confirmed this hypothesis by displaying a slight increase in potency against Cat K (>10-fold increase in potency vs 2) and a good selectivity profile against Cathepsins B, L, and S. This rationally designed inhibitor 5 also displayed increased potency in a functional bone resorption assay (10nM) versus 2 (95nM).
Transition metal compound having indenyl-containing metallocene
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, (2008/06/13)
The novel transition metal compound of the invention is represented by the following formula (I): STR1 wherein M is a transition metal; R1 is a hydrocarbon group of 2 to 6 carbon atoms, R2 is an aryl group of 6 to 16 carbon atoms; X1 and X2 are each a halogen atom or the like; and Y is a divalent hydrocarbon group, a divalent silicon-containing group or the like. An olefin polymerization catalyst component of the present invention comprises the aforementioned transition metal compound.
