459166-80-4

Upstream product

• 132313-09-8 (1R)-1-(4-bromophenyl)-3-butenylamine 
• 45708-95-0 (4-bromophenyl)methanimine 
• 1122-91-4 4-bromo-benzaldehyde 
• 459166-78-0 (1R)-N-[1-(4-bromophenyl)-3-butenyl]acetamide 

Downstream Products

• 396717-50-3 tert-butyl (2R)-2-(4-bromophenyl)-4-oxopyrrolidinecarboxylate 
• 360579-25-5 tert-butyl (2R,4R)-2-(4-bromophenyl)-4-hydroxypyrrolidinecarboxylate 
• 396717-49-0 tert-butyl (2R)-2-(4-bromophenyl)-4-hydroxypyrrolidinecarboxylate 
• 312297-45-3 (2R,4R)-1-tert-butoxycarbonyl-2-[4-[(E)-2-(tert-butoxycarbonyl)vinyl]phenyl]-4-hydroxypyrrolidine 
• 459166-79-1 tert-butyl (2R)-2-(4-bromophenyl)-4-acetoxypyrrolidinecarboxylate 

Relevant academic research and scientific papers

Synthesis of the side chain of a novel carbapenem via iodine-mediated oxidative cyclization of (1R)-N-(1-aryl-3-butenyl)acetamide.

A (2R,4S)-trans-disubstituted pyrrolidine ring system was constructed by employing iodine-mediated oxidative cyclization of (1R)-N-[1-(4-bromophenyl)-3-butenyl]acetamide 3 as a key step. The resulting diastereomeric mixture of (2R)-2-aryl-4-acetoxypyrroli