459190-08-0

Basic information

• Product Name: 6-(methylsulfonyl)-2H-1,4-benzoxazin-3(4H)-one
• CAS NO: 459190-08-0
• Molecular Weight: 227.241
• Mol File: 459190-08-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 512.5±50.0 °C(Predicted)
• Density: 1.406±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 6-(methylsulfonyl)-2H-1,4-benzoxazin-3(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(methylsulfonyl)-2H-1,4-benzoxazin-3(4H)-one(459190-08-0)
• EPA Substance Registry System: 6-(methylsulfonyl)-2H-1,4-benzoxazin-3(4H)-one(459190-08-0)

Safety Data

• Hazardous Substances Data: 459190-08-0(Hazardous Substances Data)

Upstream product

• 98-30-6 1-hydroxy-2-amino-4-methylsulphonyl-benzene 
• 598-21-0 2-Bromoacetyl bromide 
• 20945-70-4 2-methoxy-5-(methylsulfonyl)aniline 

Relevant articles and documents

Exploring Left-Hand-Side substitutions in the benzoxazinone series of 4-amino-piperidine bacterial type IIa topoisomerase inhibitors

An SAR survey at the C-6 benzoxazinone position of a novel scaffold which inhibits bacterial type IIa topoisomerase demonstrates that a range of small electron donating groups (EDG) and electron withdrawing groups (EWG) are tolerated for antibacterial activity. Cyano was identified as a preferred substituent that affords good antibacterial potency while minimizing hERG cardiac channel activity.